Evidence map›Paper›PMID 41296094›Full record

ArticleVeterinary research communications2025

Novel herpesvirus potentially associated with oral lesions in a two-toed sloth (Choloepus didactylus).

Carlos Sacristán, Laura Reisfeld, Aricia Duarte-Benvenuto, Roberta Zamana-Ramblas, Paloma Canedo, Islene Silva Santos, Jordana Barros, Fabiana Padilha, José Luiz Catão-Dias, Ana Carolina Ewbank

Abstract readCase Reports
In one paragraph

Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carlos SacristánAnimal Health Research Center, INIA-CSIC, Valdeolmos, Madrid, Spain.ORCID http://orcid.org/0000-0002-6111-6301
Laura Reisfeld *Aquario de São Paulo, São Paulo, Brazil.
Aricia Duarte-Benvenuto *School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, São Paulo, Brazil. aricia.benvenuto@gmail.com.ORCID http://orcid.org/0000-0002-2172-0838
Roberta Zamana-RamblasSchool of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-4422-321X
Paloma CanedoAquario de São Paulo, São Paulo, Brazil.
Islene Silva SantosAquario de São Paulo, São Paulo, Brazil.
Jordana BarrosAquario de São Paulo, São Paulo, Brazil.
Fabiana PadilhaAquario de São Paulo, São Paulo, Brazil.
José Luiz Catão-DiasSchool of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-2999-3395
Ana Carolina EwbankAnimal Health Research Center, INIA-CSIC, Valdeolmos, Madrid, Spain. ewbank@inia.csic.es.ORCID http://orcid.org/0000-0002-5617-9287

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 313577/2020-0Ministerio de Ciencia, Innovación y Universidades (MCIU)/Agencia Estatal de Investigación JdC2022-048632-I
6 · The paper itself

Abstract

The superorder Xenarthra comprises anteaters, sloths and armadillos, all endemic of the Americas. Despite their distinctive evolutionary history, information regarding viruses affecting this group remains scarce. Herein, we report a gammaherpesvirus infection in a two-toed sloth (Choloepus didactylus) under human care that presented recurrent oral vesicular lesions and oral candidiasis. The gammaherpesvirus identified in oral swab sample likely represents a novel species, due to the large genetic divergence when compared to the closest sequences available on public databases, and its identification in a novel host species. This finding broadens the herpesvirus host range in Xenarthra, representing the third description in this taxonomic group. Future studies should elucidate the pathogenicity of this novel herpesvirus.

Indexed as

Candidiasis, OralGammaherpesvirinaeHerpesviridae InfectionsSlothsAnimalsPhylogenyCandida spp.GammaherpesvirusMycosisSlothSouth AmericaXenarthra

Identifiers

PMID41296094
PMCPMC12657527

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.