SynthesisMolecular biology reports2025
Omics-based insights into skin ulcerative disease in sea cucumbers: a systematic review.
Synthesis in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin ulcerative disease (SUD) in sea cucumbers poses a significant threat to marine biodiversity, aquaculture sustainability, and ecosystem health. Characterized by localized lesions that can progress to extensive tissue necrosis, SUD arises from complex interactions involving microbial infections, environmental stressors, and impaired host immunity. Advances in omics technologies have greatly advanced our understanding of SUD pathogenesis. Genomics has revealed genetic determinants of susceptibility, resistance, and host pathogen interactions, while transcriptomics has provided insights into dynamic gene expression changes in immune signaling and stress response pathways. Proteomics has identified protein networks involved in inflammation, tissue remodeling, and antioxidant defenses, whereas metabolomics has uncovered metabolic shifts linked to oxidative stress, lipid remodeling, and energy imbalance. The integration of these approaches has highlighted potential biomarkers, predictive signatures, and therapeutic targets, with promising interventions such as bacteriophage therapy and IgY-based treatments. This review synthesizes current omics-driven insights and underscores the importance of multi-omics integration for advancing effective disease management strategies and enhancing aquaculture resilience.
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