Evidence map›Paper›PMID 41296065›Full record

ArticlePediatric surgery international2025

Altered enteric neurodevelopment in the Ncx knockout mouse model of intestinal neuronal dysplasia.

Naho Fujiwara, Katsumi Miyahara, Nana Nakazawa-Tanaka, Masahiko Hatano, Atsuyuki Yamataka, Go Miyano

Abstract read
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Article in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Naho FujiwaraDepartment of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. naho@juntendo.ac.jp.
Katsumi MiyaharaLaboratory of Morphology and Image Analysis, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Nana Nakazawa-TanakaDepartment of Pediatric Surgery, Juntendo University Urayasu Hospital, Chiba, Japan.
Masahiko HatanoDepartment Biomedical Science, Chiba University Graduate School of Medicine, Chiba, Japan.
Atsuyuki YamatakaDepartment of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Go MiyanoDepartment of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Funding

JSPS KAKENHI 22K08721
6 · The paper itself

Abstract

purposeIntestinal neuronal dysplasia (IND) features abnormal enteric nervous system (ENS) development and symptom overlap with Hirschsprung's disease, yet fetal-stage mechanisms remain unclear. We established a Sox10-Venus⁺/Ncx

methodsENCCs were isolated from embryonic day 13.5 (E13.5) fetal gut of Sox10-Venus⁺/Ncx

resultsNcx

conclusionThese findings demonstrate that Ncx deficiency leads to abnormal ENS development beginning during the fetal period, providing a mechanistic basis for postnatal hyperganglionosis and validating this model for studying IND pathogenesis.

Indexed as

Enteric Nervous SystemNeural CrestSodium-Calcium ExchangerAnimalsCell DifferentiationDisease Models, AnimalHirschsprung DiseaseMiceMice, KnockoutSOXE Transcription FactorsSodium-Calcium ExchangerSOXE Transcription FactorsEnteric nervous systemIntestinal neuronal dysplasiaNcx/Tlx2/Hox11L1NeurosphereSox10-Venus

Identifiers

PMID41296065

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.