Evidence map›Paper›PMID 41295848›Full record

ReviewToxins2025

Anthrax Toxin: A Pioneer of Targeted Protein Toxins.

Sandy Richter, Gudula Schmidt

Abstract readReview
In one paragraph

Review in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sandy RichterInstitute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Albertstr. 25, 79104 Freiburg, Germany.
Gudula SchmidtInstitute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Albertstr. 25, 79104 Freiburg, Germany.ORCID 0000-0002-2876-0189

Funding

Deutsche Forschungsgemeinschaft SCHM 1385/12-2
6 · The paper itself

Abstract

With anthrax toxin as a pioneer, several bacterial toxins have been engineered to deliver proteins of interest into the cytosol of specific mammalian cells. Such targeted protein toxins combine the ability to deliver cargo molecules into cells with designed receptor interaction for targeting selected cells. This review summarizes the actual knowledge of modified anthrax toxin. Moreover, the significant efforts which have been made to utilize other bacterial toxins are discussed. The targeted protein toxins described in this review include single-chain toxins, pore-forming toxins, and injection machineries.

Indexed as

Antigens, BacterialBacterial ToxinsAnimalsHumansanthrax toxinAntigens, BacterialBacterial Toxinsanthrax toxincell targetingprotein transport

Identifiers

PMID41295848
PMCPMC12656542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.