Evidence map›Paper›PMID 41295840›Full record

ArticleToxins2025

Leptin and Adiponectin as Uremic Adipokines: Associations with Survival in a Prospective Hemodialysis Cohort.

Thuy-Anh V Bui, Amy S You, Sara S Kalantar, Jihoon Yoon, Yoko Narasaki, John Sy, Ramy Hanna, Andrea Daza, Yalitzi Guerrero, Anyssa Dang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Thuy-Anh V BuiBaylor College of Medicine, Houston, TX 77030, USA.
Amy S YouDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA.
Sara S KalantarUniversity of California Berkeley, Berkeley, CA 94720, USA.
Jihoon YoonDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA.ORCID 0009-0007-9453-882X
Yoko NarasakiDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA.ORCID 0000-0002-2571-3803
John SyDivision of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Orange, CA 92868, USA.ORCID 0000-0002-3451-2413
Ramy HannaDivision of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Orange, CA 92868, USA.
Andrea DazaDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA.
Yalitzi GuerreroDivision of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Orange, CA 92868, USA.
Anyssa DangDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA.
Ria AroraDivision of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Orange, CA 92868, USA.
Danh V NguyenDivision of General Internal Medicine, University of California Irvine, Orange, CA 92868, USA.
Kamyar Kalantar-ZadehDivision of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Orange, CA 92868, USA.ORCID 0000-0002-8666-0725
Connie M RheeDivision of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Orange, CA 92868, USA.ORCID 0000-0002-9703-6469

Funding

Multilevel Time-Dynamic Modeling of Hospitalization and Survival in Patients on DialysisR01DK092232 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KURUM, ESRA, NGUYEN, DANH V · 2011 to 2025
$4.9M
A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis PatientsR01DK122767 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RHEE, CONNIE MEEYOUNG · 2019 to 2023
$3.3M
Defining Optimal Transitions of Care in Advanced Kidney Disease: Conservative Management vs. Dialysis ApproachesR01DK124138 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KALANTAR-ZADEH, KAMYAR, RHEE, CONNIE MEEYOUNG · 2020 to 2024
$2.9M
MALNUTRITION, DIET AND RACIAL DISPARITIES IN CKDK24DK091419 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI KALANTAR-ZADEH, KAMYAR · 2011 to 2020
$1.8M
Plant-Focused Nutrition in Patients with Diabetes and Chronic Kidney Disease (PLAFOND Study): A Pilot/Feasibility StudyR01DK132875 · NIDDK · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI KALANTAR-ZADEH, KAMYAR, RHEE, CONNIE MEEYOUNG · 2023 to 2025
$836k
Continuous Glucose Monitoring in Dialysis Patients to Overcome Dysglycemia Trial (CONDOR TRIAL)R01DK132869 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KALANTAR-ZADEH, KAMYAR, RHEE, CONNIE MEEYOUNG · 2023 to 2025
$781k
NIDDK NIH HHS K24 DK091419NIDDK NIH HHS R01 DK092232NIDDK NIH HHS R01 DK122767NIDDK NIH HHS R01 DK124138NIDDK NIH HHS R01 DK132869NIDDK NIH HHS R01 DK132875NIH/NIDDK NIH/NIDDK grants K24-DK091419 (KKZ), R01-DK122767 (CMR), R01-DK124138 (CMR, KKZ), R01-DK132869 (CMR, KKZ), R01-DK132875 (KKZ, CMR), and R01-DK092232 (DVN).
6 · The paper itself

Abstract

backgroundWhile experimental models show that leptin and adiponectin have inverse effects on the cardiovascular system, it has been suggested that the leptin-to-adiponectin (L/A) ratio may be an important predictor of cardiovascular disease and death. Higher circulating leptin and adiponectin levels are observed in uremia due to decreased renal degradation and/or clearance and increased production. We sought to examine the association between the L/A ratio and mortality in a prospective hemodialysis cohort.

methodsAmong a prospective cohort of 448 hemodialysis patients from the NIH "Malnutrition, Diet, and Racial Disparities in Chronic Kidney Disease (CKD) (MADRAD) study who underwent leptin and adiponectin measurements, we examined characteristics associated with high leptin and adiponectin (defined as the highest tertile) using logistic regression. We then examined the association of L/A ratio levels (categorized as tertiles) with all-cause mortality using Cox regression.

resultsMultivariable logistic regression analyses showed female sex, diabetes, presence of an arteriovenous fistula/graft, and lower serum albumin, IL-6, and adiponectin were associated with high leptin, whereas female sex, longer vintage, Black race, higher IL-6, and lower leptin were associated with high adiponectin. When examining L/A ratios, the highest tertile was associated with lower mortality in case-mix Cox models (ref: lowest tertile): HR (95% CI) 0.14 (0.06-0.35). These associations were robust in analyses that additionally adjusted for laboratory covariates: (HR 95% CI) 0.18 (0.07-0.46).

conclusionsIn a prospective cohort of hemodialysis patients, inflammation and malnutrition markers were associated with lower leptin and higher adiponectin levels. Additionally, high L/A ratio levels were associated with lower mortality. Further studies are needed to determine the mechanisms relating adipocytokines, inflammation and nutrition, and survival in this population.

Indexed as

AdiponectinLeptinRenal DialysisRenal Insufficiency, ChronicUremiaAgedBiomarkersFemaleHumansMaleMiddle AgedProspective StudiesAdiponectinADIPOQ protein, humanBiomarkersLEP protein, humanLeptinadipokinesadiponectinchronic kidney diseasehemodialysisleptin

Identifiers

PMID41295840
PMCPMC12656480

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.