ArticleVeterinary sciences2025
Serum Paraoxonase-1 (PON-1) in Dogs: Frequency of Decreased Values in Clinical Practice and Prognostic Significance.
Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Serum activity of paraoxonase-1 (PON-1) decreases in canine inflammation. This study aimed to evaluate how frequently PON-1 activity is reduced across different disease categories and to assess its potential prognostic significance. PON-1 activity was measured in 482 samples (435 first visit, 47 follow-up) collected during routine clinical activities. The emergency/first-opinion unit (EF) had the highest frequency of low values (18.3%) and lower median PON-1 activity (170.3 U/mL) compared with other units. The proportion of lower values and median PON-1 values were, respectively, significantly higher and lower in acute/severe diseases compared with chronic/mild diseases (13.3 vs. 7.1%; 177.0 vs. 192.9 U/mL) and in hospitalized compared with non-hospitalized dogs (27.7 vs. 4.5%; 150.0 vs. 193.0 U/mL). Low PON-1 activity may predict the need for hospitalization: values < 45.7 U/mL have a likelihood ratio of 14.4. The proportion of lower values and the median Paraoxonase-1 activity did not differ between survivors and non-survivors (18.2 vs. 25.0%; 162.0 vs. 161.3 U/mL). However, PON-1 activity diminished during hospitalization only in non-survivors. PON-1 activity should be measured in routine practice, especially in the EF; hospitalization may be warranted when results are markedly low. Decreases in PON-1 activity during hospitalization may suggest a negative outcome.
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