Evidence map›Paper›PMID 41295667›Full record

ArticleVeterinary sciences2025

MicroRNA Expression Profiling in Canine Myxomatous Mitral Valve Disease Highlights Potential Diagnostic Tool and Molecular Pathways.

Gabriella Guelfi, Noemi Santarelli, Camilla Capaccia, Federica Valeri, Domenico Caivano, Elvio Lepri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriella GuelfiDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, Italy.ORCID 0000-0003-3695-9275
Noemi SantarelliClinique Vétérinaire Univet Karukéra, 13090 Aix-en-Provence, France.
Camilla CapacciaDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, Italy.ORCID 0000-0002-1040-6245
Federica ValeriDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, Italy.ORCID 0009-0005-7940-8416
Domenico CaivanoDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, Italy.ORCID 0000-0001-8540-4853
Elvio LepriDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, Italy.ORCID 0000-0001-8478-8154

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myxomatous mitral valve disease (MMVD) is the most common acquired cardiac disoder in dogs and a relevant model for human mitral valve disease. However, the molecular drivers of disease progression remain unclear, and reliable biomarkers for early diagnosis still hamper clinical management. This study investigated microRNA (miRNA) expression directly in histologically characterized mitral valve tissues. Formalin-fixed paraffin-embedded samples were obtained from control dogs (

Indexed as

biomarkerscanine myxomatous mitral valve diseasedogextracellular matrix remodelingFFPE tissuesmicroRNA

Identifiers

PMID41295667
PMCPMC12656886

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.