ArticleNanomaterials (Basel, Switzerland)2025
Curcumin-Loaded Polysaccharide Nanoparticles Enhance Aqueous Dispersibility and In Vitro Cytotoxicity in Breast Cancer Cell Lines.
Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Curcumin (CUR) is a natural compound with anticancer potential; however, its poor water solubility, instability, and rapid degradation limit its therapeutic use. To address these issues, we developed CUR-loaded nanoparticles (CUR-NPs) based on chitosan, hyaluronic acid, and alginate, the TEM-measured diameter of 29.3 ± 9.0 nm. Dynamic light scattering (DLS) analysis further confirmed good aqueous dispersibility, revealing hydrodynamic diameters of 39.8 ± 7.1 nm for UL-NPs and 46.1 ± 18.1 nm for CUR-NPs. Cytotoxicity assays revealed significant anticancer activity in both MCF-7 and MDA-MB-231 cells, with IC
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