Evidence map›Paper›PMID 41295645›Full record

ArticleNanomaterials (Basel, Switzerland)2025

Advancing Skin Rejuvenation Through Ultrasound-Enhanced Non-Invasive Delivery of Hyaluronic Acid Nanoparticles.

Leah Shimonov, Chen Benafsha, Shir Harel, Ksenia M Yegodayev, Uzi Hadad, Riki Goldbart, Tamar Traitel, Yuval Krieger, Moshe Elkabets, Joseph Kost

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leah ShimonovDepartment of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Chen BenafshaDepartment of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Shir HarelDepartment of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Ksenia M YegodayevThe Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.ORCID 0000-0003-0721-838X
Uzi HadadThe Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.ORCID 0000-0002-7643-1275
Riki GoldbartDepartment of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Tamar TraitelDepartment of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Yuval KriegerDepartment of Plastic Surgery, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Moshe ElkabetsThe Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.ORCID 0000-0003-3634-9098
Joseph KostDepartment of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.ORCID 0000-0002-7854-533X

Funding

the Israel Innovation Authority and Ben-Gurion University Science Accelerator 8107671
6 · The paper itself

Abstract

High-molecular-weight hyaluronic acid (HMw-HA) is widely used for skin rejuvenation and anti-aging. However, its rapid degradation and <24 h cutaneous residence limit its therapeutic potential. Cross-linked HA fillers were developed to improve longevity, but their high viscosity and invasive administration may reduce biocompatibility and patient comfort. To overcome these challenges, we developed a biocompatible nanocarrier based on quaternized starch (Q-starch) that encapsulates linear HMw-HA into nanoparticles (NPs) of ~100 nm with a ζ-potential of ~-35 mV. These NPs retained spherical morphology over seven days without aggregation. The resulting HMw-HA-NPs significantly improved HA stability and extended its skin residence time compared to commercially available HA, while preserving its biological function to stimulate collagen production in murine models. To enable non-invasive delivery, we applied low-frequency ultrasound (LFUS), which transiently enhanced skin permeability, facilitated deeper NPs penetration, and further elevated collagen at day 14. Altogether, this strategy offers a promising needle-free alternative to traditional HA treatments by improving stability, skin penetration, and therapeutic efficacy. The combination of HMw-HA-NPs with LFUS addresses key limitations of current dermo-esthetic therapies and supports the development of patient-friendly skin rejuvenation technologies.

Indexed as

high molecular weight hyaluronic acidlow frequency ultrasoundmodified starchnanoparticlesresidence time

Identifiers

PMID41295645
PMCPMC12655556

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.