Evidence map›Paper›PMID 41295590›Full record

ArticleTropical medicine and infectious disease2025

In Vitro and Ultrastructural Evaluation of the Cytotoxic and Antileishmanial Activities of Thiosemicarbazone Compounds Against Promastigotes and Axenic Amastigotes of

Janderson Weydson Lopes Menezes da Silva, Andréa Regina Alves da Rocha Diniz, Alberon Ribeiro de Araújo, Gabriel Gazzoni Araújo Gonçalves, Dyana Leal Veras, Marton Kaique de Andrade Cavalcante, Jana Messias Sandes, Iranildo José da Cruz Filho, Diego Santa Clara Marques, Maria do Carmo Alves de Lima and 3 more

Abstract read
In one paragraph

Article in Tropical medicine and infectious disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Janderson Weydson Lopes Menezes da SilvaLaboratório de Doenças Parasitárias, Infecciosas e Não-Infecciosas, Departamento de Parasitologia, Instituto Aggeu Magalhães-IAM-FIOCRUZ, Recife 50740-465, PE, Brazil.ORCID 0000-0002-3853-5567
Andréa Regina Alves da Rocha DinizLaboratório de Doenças Parasitárias, Infecciosas e Não-Infecciosas, Departamento de Parasitologia, Instituto Aggeu Magalhães-IAM-FIOCRUZ, Recife 50740-465, PE, Brazil.
Alberon Ribeiro de AraújoLaboratório de Doenças Parasitárias, Infecciosas e Não-Infecciosas, Departamento de Parasitologia, Instituto Aggeu Magalhães-IAM-FIOCRUZ, Recife 50740-465, PE, Brazil.ORCID 0000-0002-7241-9543
Gabriel Gazzoni Araújo GonçalvesLaboratório de Microscopia Eletrônica, Instituto Keizo Asami-iLIKA-UFPE, Recife 50670-901, PE, Brazil.
Dyana Leal VerasLaboratório de Doenças Parasitárias, Infecciosas e Não-Infecciosas, Departamento de Parasitologia, Instituto Aggeu Magalhães-IAM-FIOCRUZ, Recife 50740-465, PE, Brazil.ORCID 0000-0001-8478-8496
Marton Kaique de Andrade CavalcanteLaboratório de Doenças Parasitárias, Infecciosas e Não-Infecciosas, Departamento de Parasitologia, Instituto Aggeu Magalhães-IAM-FIOCRUZ, Recife 50740-465, PE, Brazil.ORCID 0000-0001-9995-7352
Jana Messias SandesLaboratório de Microscopia Eletrônica, Instituto Keizo Asami-iLIKA-UFPE, Recife 50670-901, PE, Brazil.ORCID 0000-0003-0799-8451
Iranildo José da Cruz FilhoLaboratório de Planejamento em Química Medicinal, Departamento de Antibióticos-UFPE, Recife 50670-901, PE, Brazil.
Diego Santa Clara MarquesLaboratório de Planejamento em Química Medicinal, Departamento de Antibióticos-UFPE, Recife 50670-901, PE, Brazil.
Maria do Carmo Alves de LimaLaboratório de Planejamento em Química Medicinal, Departamento de Antibióticos-UFPE, Recife 50670-901, PE, Brazil.
Ana Paula Sampaio FeitosaSecretaria de Educação do Rio Grande do Norte, Mossoró 59064-901, RN, Brazil.
Luiz Carlos AlvesLaboratório de Doenças Parasitárias, Infecciosas e Não-Infecciosas, Departamento de Parasitologia, Instituto Aggeu Magalhães-IAM-FIOCRUZ, Recife 50740-465, PE, Brazil.
Fábio André BraynerLaboratório de Doenças Parasitárias, Infecciosas e Não-Infecciosas, Departamento de Parasitologia, Instituto Aggeu Magalhães-IAM-FIOCRUZ, Recife 50740-465, PE, Brazil.ORCID 0000-0002-8017-6780

Funding

Fundação de Amparo à Ciência e Tecnologia de Pernambuco IBPG-0221-2.13/2020PROEP-IAM/FIOCRUZ 136151355553442
6 · The paper itself

Abstract

Leishmaniasis remains a global health challenge, and the search for effective and selective therapeutic agents is crucial. This study evaluated the in vitro antileishmanial and cytotoxic activities of thiosemicarbazone compounds (LT-70, LT-73, LT-75, and LT-89) against

Indexed as

apoptosiscytotoxicityimmunomodulationmitochondrial dysfunctionparasite ultrastructurethiosemicarbazones

Identifiers

PMID41295590
PMCPMC12656565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.