Evidence map›Paper›PMID 41295576›Full record

ArticleTropical medicine and infectious disease2025

Comparison of Interferon-Gamma Release Assay and Tuberculin Skin Test in Screening for Latent Tuberculous Infection Among Students from High-Burden Areas: A Prospective Head-to-Head Study in Qingdao, China.

Zhongdong Wang, Kun Zhang, Haiyan Sun, Xuekui Li, Song Song, Meng Chen, Honghong Xu, Huaqiang Zhang, Yu Pang, Xiaoqi Dai

Abstract read
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In one paragraph

Article in Tropical medicine and infectious disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhongdong WangQingdao Prefectural Center for Disease Control and Prevention, Qingdao Institute of Prevention Medicine, Qingdao 266000, China.
Kun ZhangBeijing Key Laboratory for Key Technologies in Tuberculosis Prevention and Control, Department of Bacteriology and Immunology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Haiyan SunQingdao Prefectural Center for Disease Control and Prevention, Qingdao Institute of Prevention Medicine, Qingdao 266000, China.
Xuekui LiQingdao Prefectural Center for Disease Control and Prevention, Qingdao Institute of Prevention Medicine, Qingdao 266000, China.
Song SongQingdao Prefectural Center for Disease Control and Prevention, Qingdao Institute of Prevention Medicine, Qingdao 266000, China.
Meng ChenQingdao Prefectural Center for Disease Control and Prevention, Qingdao Institute of Prevention Medicine, Qingdao 266000, China.
Honghong XuQingdao Prefectural Center for Disease Control and Prevention, Qingdao Institute of Prevention Medicine, Qingdao 266000, China.
Huaqiang ZhangQingdao Prefectural Center for Disease Control and Prevention, Qingdao Institute of Prevention Medicine, Qingdao 266000, China.ORCID 0000-0002-6566-3468
Yu PangBeijing Key Laboratory for Key Technologies in Tuberculosis Prevention and Control, Department of Bacteriology and Immunology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.ORCID 0000-0001-6803-9807
Xiaoqi DaiQingdao Prefectural Center for Disease Control and Prevention, Qingdao Institute of Prevention Medicine, Qingdao 266000, China.

Funding

Qingdao Medical and Health Research Program Project 2023-WJZD128
6 · The paper itself

Abstract

backgroundIdentifying latent tuberculosis infection (LTBI) is critical for pediatric TB control in China, especially among students from high-burden areas. With no gold-standard test, we compared the tuberculin skin test (TST) and interferon-gamma release assay (IGRA), focusing on factors related to test discordance. MATERIALS AND

methodsTST was administered to 1047 local and 900 migrant students; all migrants also received IGRA. TST cutoffs of 5 mm and 10 mm were applied. Agreement was measured using Cohen's Kappa, and determinants of discordance were analyzed with binary logistic regression.

resultsMigrant students had higher TST positivity than locals (28.89% vs. 19.67%,

conclusionsUsing a 12 mm cutoff improves TST accuracy for students from high-burden areas. IGRA should be preferred for individuals with BCG vaccination history.

Indexed as

high tuberculosis burden areasinterferon-gamma release assayslatent tuberculosis infectionstudentstuberculin skin test

Identifiers

PMID41295576
PMCPMC12656460

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.