Evidence map›Paper›PMID 41295521›Full record

ArticleVaccines2025

Genomic Analysis of Glycosyltransferases Responsible for Galactose-α-1,3-Galactose Epitopes in

Xinjia Mai, Nian Wang, Chenxi Zhu, Yue Ma, Zhongrui Ma, Lan Yin, Dapeng Zhou

Abstract read
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinjia MaiKey Laboratory of Pathogen and Host-Interactions, Department of Immunology and Pathogen Biology, Ministry of Education, Tongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, China.ORCID 0009-0006-7752-0233
Nian WangKey Laboratory of Pathogen and Host-Interactions, Department of Immunology and Pathogen Biology, Ministry of Education, Tongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, China.
Chenxi ZhuKey Laboratory of Pathogen and Host-Interactions, Department of Immunology and Pathogen Biology, Ministry of Education, Tongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, China.
Yue MaKey Laboratory of Pathogen and Host-Interactions, Department of Immunology and Pathogen Biology, Ministry of Education, Tongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, China.
Zhongrui MaSchool of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China.
Lan YinKey Laboratory of Pathogen and Host-Interactions, Department of Immunology and Pathogen Biology, Ministry of Education, Tongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, China.
Dapeng ZhouKey Laboratory of Pathogen and Host-Interactions, Department of Immunology and Pathogen Biology, Ministry of Education, Tongji University School of Medicine, 500 Zhennan Road, Shanghai 200331, China.

Funding

Fundamental Research Funds for the Central Universities 22120250317National Key Research and Development Plan 2021YFE0200500National Natural Science Foundation of China 31870972National Natural Science Foundation of China 92359203Shanghai Science and Technology Commission 20410713500Sino-German Scientific Research Program M0693
6 · The paper itself

Abstract

backgroundThe origin of natural anti-galactose-α-1,3-galactose (anti-Gal) antibodies in humans is only partially understood. The gut microbiome has been proposed as an important source of galactose-α-1,3-galactose (αGal) epitopes that drive the maturation of anti-Gal-reactive B cells. Certain bacteria expressing αGal epitopes, notably

methodsWe conducted a genomic analysis to identify α1,3-galactosyltransferase (α3GalT1) genes in

resultsGenomic analysis revealed the presence of α3GalT1 genes in

conclusionsThese results provide genetic and immunological evidence that αGal epitopes derived from

Indexed as

23-valent Streptococcus pneumoniae polysaccharide vaccineanti-Gal antibodiesStreptococcus pneumoniaeα1,3 galactose

Identifiers

PMID41295521
PMCPMC12656782

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.