ArticleVaccines2025
Yeast Display Reveals Plentiful Mutations That Improve Fusion Peptide Vaccine-Elicited Antibodies Beyond 59% HIV-1 Neutralization Breadth.
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In one paragraph
Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
20 authors.
Camila T FrançaThe Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.ORCID 0000-0001-5885-4410
Sergei PletnevVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Bharat MadanThe Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
Phinikoula S KatsambaDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0003-3981-1604
Krisha McKeeVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Nicholas C MoranoDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Baoshan ZhangVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Fabiana BahnaDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Tatsiana BylundVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-2065-2773
Bob C LinVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Mark K LouderVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Seetha MannepalliDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Rajani NimraniaThe Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
Sijy O'DellVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-4951-8471
Nicole A Doria-RoseVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Peter D KwongVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-3560-232X
Lawrence ShapiroDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Zizhang ShengAaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-3253-3309
Tongqing ZhouVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3935-4637
Brandon J DeKoskyThe Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.ORCID 0000-0001-6406-0836
Funding
Strategies for targeting T follicular helper cells to improve HIV Env vaccine immunogenicity and efficacyP01AI181044 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENNIS J. HARTIGAN-O'CONNOR · 2025 to 2026
$11.0MDissecting the mechanisms of HIV resistance in vivo to broadly neutralizing antibodiesU01AI169587 · NIAID · UNIVERSITY OF MINNESOTA · PI Priyamvada Acharya, Brandon James DeKosky · 2022 to 2026
$7.8MPotent broadly neutralizing antibody development against the HIV-1 fusion peptide epitopeR01AI181684 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Brandon James DeKosky · 2023 to 2026
$3.0MThe influence of evolutionary landscapes on protective antibody developmentR01AI141452 · NIAID · UNIVERSITY OF COLORADO · PI WHITEHEAD, TIMOTHY ANDREW · 2019 to 2023
$2.8MComprehensive analysis of human adaptive immune receptors to elucidate correlates of Epstein-Barr virus disease suppressionDP5OD023118 · OD · UNIVERSITY OF KANSAS LAWRENCE · PI DEKOSKY, BRANDON JAMES · 2016 to 2022
$2.2MPotent Antibody Protection Against P. falciparum and P. vivax MalariaR01AI192975 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Brandon James DeKosky · 2025 to 2026
$1.6MRapid antibody screening systems to identify and engineer antiviral protectionR21AI166396 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI DEKOSKY, BRANDON JAMES · 2022 to 2023
$850kComprehensive molecular and functional analyses of anti-HIV-1 broadly neutralizing antibody repertoiresR21AI143407 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI DEKOSKY, BRANDON JAMES, FORREST, MARCUS LAIRD · 2019 to 2020
$435kNIAID NIH HHS P01 AI181044NIAID NIH HHS R01 AI141452NIAID NIH HHS R01 AI181684NIAID NIH HHS R01 AI192975NIAID NIH HHS R21 AI143407NIAID NIH HHS R21 AI166396NIAID NIH HHS U01 AI169587NIH HHS 1R01AI181684NIH HHS DP5 OD023118NIH HHS DP5OD023118NIH HHS R01AI141452NIH HHS R01AI192975NIH HHS R21AI143407NIH HHS R21AI166396NIH HHS U01AI169587
Abstract
PubMed holds no abstract for this paper.
Indexed as
antibody improvementbroadly neutralizing antibodyepitopefusion peptideHIV-1 vaccineparatopeyeast display
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.