ArticleMarine drugs2025
A Marine-Derived Sterol, Ergosterol, Mitigates UVB-Induced Skin Photodamage via Dual Inhibition of NF-κB and MAPK Signaling.
Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Development of a Marine Algae-based Facial Cream Enriched With Phycoerythrin: Physicochemical Properties and Biological Activities.Marine biotechnology (New York, N.Y.) · 2026Article
- Neoagarotetraose from Marine Red Algae Ameliorates UVB-Induced Skin Barrier Damage in Mice and HaCaT Keratinocytes.Marine biotechnology (New York, N.Y.) · 2026Article
- Isaridin E Protects Against UVB-Induced Photoaging by Activating Wnt/β-Catenin Signaling Pathway and Alleviating Mitochondrial Dysfunction.Marine drugs · 2026Article
- Article
- From Sunlight to Signaling: Evolutionary Integration of Vitamin D and Sterol Metabolism.Metabolites · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundUltraviolet B (UVB) radiation induces oxidative stress, inflammation, and collagen degradation in skin, leading to photodamage. Ergosterol (ERG)-a sterol widely distributed in fungi and algae, including numerous marine species-possesses antioxidant and anti-inflammatory activities, but its photoprotective mechanisms remain unclear.
methodsUsing integrated
resultsERG treatment preserved keratinocyte viability, reduced reactive oxygen species, and suppressed pro-inflammatory mediators after UVB exposure. In mice, topical ERG significantly attenuated epidermal hyperplasia, maintained tight-junction integrity, and inhibited collagen matrix degradation. Mechanistically, ERG exerted dual inhibition of the nuclear factor kappa B (NF-κB) pathway, which mediates inflammation, and the mitogen-activated protein kinase (MAPK) pathway, which regulates collagen degradation.
conclusionsThese findings identify ERG as a marine-derived sterol with potent photoprotective activity that simultaneously targets oxidative stress, inflammation, and extracellular matrix damage, highlighting its promise as a natural compound for dermatological applications and aligning with ongoing efforts to explore marine-derived agents against skin oxidative stress and inflammation.
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Registered trials
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