Evidence map›Paper›PMID 41295405›Full record

ArticleMarine drugs2025

Total Synthesis of Peniterphenyls A and E.

Huayan Xu, Yuyue Li, Yuecheng Fang, Juan Liu, Junfeng Wang, Shengrong Liao, Yonghong Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huayan XuWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yuyue LiResearch Center for Marine Microbes, Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Yuecheng FangResearch Center for Marine Microbes, Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Juan LiuResearch Center for Marine Microbes, Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Junfeng WangResearch Center for Marine Microbes, Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.ORCID 0000-0001-6702-5366
Shengrong LiaoResearch Center for Marine Microbes, Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.ORCID 0000-0003-4393-3823
Yonghong LiuWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.ORCID 0000-0001-8327-3108

Funding

Guangdong Basic and Applied Basic Research Foundation 2022B1515120075, 2022B1515130008Hainan Provincial Natural Science Foundation of China 823CXTD393National Natural Science Foundation of China 82373789, U23A20528
6 · The paper itself

Abstract

Our previously discovered marine natural products, peniterphenyls A and E, exhibit superior anti-herpes simplex virus 1/2 (HSV 1/2) activity, probably via interference with virus adsorption and membrane fusion to host cells. Their clear mechanism mode still remains unresolved due to its limited availability from nature. This study establishes their first site-selective chemical total syntheses, affording peniterphenyls A and E in overall yields of 4.5% (over thirteen steps) and 2.3% (over twelve steps), respectively. A nucleophilic aromatic substitution (S

Indexed as

Antiviral AgentsBenzofuransBiological ProductsCatalysisHerpesvirus 1, HumanPalladiumAntiviral AgentsBenzofuransBiological ProductsdibenzofuranPalladiumcross-couplingPd catalysisp-terphenylssite-selectivitySNArtotal synthesis

Identifiers

PMID41295405
PMCPMC12654094

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.