Evidence map›Paper›PMID 41295374›Full record

ArticleJournal of cardiovascular development and disease2025

Cardiomyocyte Nuclear Pleomorphism in a Mouse Model of Inherited Hypertrophic Cardiomyopathy.

Jamie R Johnston, Isabella Leite Coscarella, Carson L Rose, Yun Shi, Hosna Rastegarpouyani, Karissa M Dieseldorff Jones, Jennifer M Le Patourel, Feyikemi Ogunfuwa, Adriano S Martins, Kathryn M Crotty and 9 more

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jamie R JohnstonDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0002-3563-640X
Isabella Leite CoscarellaDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-9706-9319
Carson L RoseDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.ORCID 0009-0000-2033-6087
Yun ShiDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0002-2970-2458
Hosna RastegarpouyaniInstitute for Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0003-1358-9910
Karissa M Dieseldorff JonesDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0002-9124-6246
Jennifer M Le PatourelDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.ORCID 0009-0002-9714-4117
Feyikemi OgunfuwaDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-7063-6977
Adriano S MartinsDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-5747-5945
Kathryn M CrottyDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0002-9461-4032
Katherine M Ward MollaDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.ORCID 0009-0004-0128-2000
Tyler R ReinosoDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-7923-3971
Taylor L WaldmannDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.ORCID 0009-0000-4153-3215
Jerome IriantoDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0002-4804-7225
Yue Julia WangDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0003-2641-6904
Lili WangVanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Björn C KnollmannVanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.ORCID 0000-0003-4956-9735
Jose R PintoDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-9092-4976
Prescott Bryant ChaseDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-9701-561X

Funding

Toward a Mechanism-Based Approach to Treating Cardiac ArrhythmiaR35HL144980 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2019 to 2025
$7.1M
The mechanisms of cardiac thin filament regulation in health and disease.R01HL160966 · NHLBI · OLD DOMINION UNIVERSITY · PI CHASE, P. BRYANT, GALKIN, VITOLD · 2022 to 2025
$2.3M
Modulators of Cardiomyopathic DiseasesR01HL128683 · NHLBI · FLORIDA STATE UNIVERSITY · PI PINTO, JOSE RENATO · 2016 to 2020
$1.8M
Isolation, Characterization and Reconstruction of Vertebrate Striated Muscle Myosin FilamentsR21AR077802 · NIAMS · FLORIDA STATE UNIVERSITY · PI PINTO, JOSE RENATO, TAYLOR, KENNETH ALLEN · 2020 to 2021
$356k
Reversal of Hypertrophic Cardiomyopathy via Conditional Ablation of Cardiac Myosin Light Chain KinaseF31HL137408 · NHLBI · FLORIDA STATE UNIVERSITY · PI DIESELDORFF JONES, KARISSA M · 2017 to 2019
$105k
American Heart Association 19PRE34380628NHLBI NIH HHS F31 HL137408NHLBI NIH HHS R01 HL128683NHLBI NIH HHS R01 HL160966NHLBI NIH HHS R35 HL144980NIAMS NIH HHS R21 AR077802U. S. National Institutes of Health, National Heart, Lung, and Blood Institute HL128683U. S. National Institutes of Health, National Heart, Lung, and Blood Institute HL160966
6 · The paper itself

Abstract

Mutations in genes encoding sarcomeric proteins are a common cause of cardiomyopathy and sudden cardiac death in humans. We evaluated the hypothesis that myofilament dysfunction is coupled to morphological and functional alterations of cardiomyocyte nuclei in a

Indexed as

hiPSC-derived cardiomyocytesinherited cardiomyopathynucleus mechanicsTNNC1troponin

Identifiers

PMID41295374
PMCPMC12653334

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.