ReviewJournal of cardiovascular development and disease2025
Role of Coronary Artery Calcium Score CT in Risk Stratification of Asymptomatic Individuals.
Review in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe evaluation of coronary artery disease has undergone significant transformation in recent years, with increasing emphasis on the detection and characterization of subclinical atherosclerotic plaques in order to improve cardiovascular prevention. In this context, coronary computed tomography (CT) has emerged as a promising tool. Coronary artery calcium scoring (CACS) is a powerful predictor of cardiovascular events.
methodsA narrative review on the role of CACS in risk stratification of asymptomatic adults is conducted through a structured search in PubMed (2010-2025), including guidelines, consensus documents, observational studies, and clinical trials published in English.
resultsCACS reliably identifies subclinical atherosclerosis and stratifies cardiovascular risk in asymptomatic individuals. Large studies, including the Multi-Ethnic Study of Atherosclerosis (MESA), demonstrate that CACS predicts 10-year cardiovascular events, improves risk reclassification beyond traditional scores, and identifies very low-risk individuals (those with a CAC of 0). Moreover, CACS retains prognostic value across age, sex, and ethnic subgroups; supports decision-making for lipid-lowering therapy and aspirin use; and correlates with non-gated CT assessments. Progression of CAC further informs risk, although its interpretation is influenced by preventive therapies and is complemented by more comprehensive plaque imaging.
conclusionsCACS is a validated tool for detecting subclinical atherosclerosis and refining cardiovascular risk in asymptomatic individuals. CACS thus complements traditional risk scores and represents a key component of contemporary and future cardiovascular prevention in clinical practice.
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