Evidence map›Paper›PMID 41295361›Full record

ArticleJournal of cardiovascular development and disease2025

Use of Echocardiography Under Hypoxic Stress Without Exercise to Assess Right to Left Shunting.

Cecilia Villa Etchegoyen, Rachel E Wraith, Lisa S Brown, Karen K Breznak, Rohit Mital, Steven J Lester, Chadi Ayoub, Said Alsidawi, Justin N Shipman, Juan M Farina and 2 more

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cecilia Villa EtchegoyenDepartment of Cardiovascular Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.ORCID 0000-0003-0278-2192
Rachel E WraithDepartment of Cardiovascular Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.
Lisa S BrownDepartment of Cardiovascular Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.
Karen K BreznakAerospace Medicine Program, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.
Rohit MitalDepartment of Cardiovascular Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.ORCID 0000-0001-7960-8163
Steven J LesterDepartment of Cardiovascular Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.
Chadi AyoubDepartment of Cardiovascular Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.
Said AlsidawiDepartment of Cardiovascular Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.ORCID 0000-0001-8750-7880
Justin N ShipmanDepartment of Cardiovascular Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.
Juan M FarinaDepartment of Cardiovascular Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.ORCID 0000-0002-5824-8485
Reza ArsanjaniDepartment of Cardiovascular Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.ORCID 0000-0001-7081-4286
Jan StepanekAerospace Medicine Program, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.ORCID 0000-0001-5748-6150

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute exposure to hypoxia will induce right ventricular (RV) hemodynamic changes and may increase the degree of right-to-left shunting, which can contribute to dyspnea at altitude. In this retrospective study, 125 patients (median age 66 years; 50.4% women) with unexplained dyspnea at altitude underwent hypoxic simulation testing (HST) with transthoracic echocardiography (TTE). During simulated hypoxia (mode (Min-Max) altitude: 8000 (6000-18,000) ft, were observed a significant decrease in oxygen saturation (97% (95-98) vs. 88% (82-92),

Indexed as

dyspneaechocardiographyhigh altitudehypoxic simulation testingshuntstress test

Identifiers

PMID41295361
PMCPMC12653421

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.