Structural Insights into the Glycosylphosphatidylinositol Mannosyltransferase I Complex from

Hui Sun, Weihong Wu, Xiaomei Li, Yang Deng, Jiarong Huang, Meng Yin, Zhaofeng Yan

Abstract read

In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hui SunSchool of Biomedical Sciences, Hunan University, Changsha 410082, China.ORCID 0009-0006-7850-7655

Weihong WuSchool of Biomedical Sciences, Hunan University, Changsha 410082, China.

Xiaomei LiShanxi Academy of Advanced Research and Innovation, Taiyuan 030032, China.

Yang DengHunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs, The Third Hospital of Changsha, Changsha 410118, China.

Jiarong HuangSchool of Biomedical Sciences, Hunan University, Changsha 410082, China.

Meng YinSchool of Biomedical Sciences, Hunan University, Changsha 410082, China.

Zhaofeng YanSchool of Biomedical Sciences, Hunan University, Changsha 410082, China.ORCID 0000-0001-9054-3313

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global rise in resistance to first-line antifungal agents highlights the urgent need for new therapeutic strategies. Glycosylphosphatidylinositol (GPI)-anchored protein biosynthesis is an attractive target. The GPI mannosyltransferase I (GPI-MT-I), composed of Gpi14 and Pbn1, catalyzes the essential first mannose transfer from dolichol-phosphomannose (Dol-P-Man) to the GPI precursor. This initial mannosylation is critical for fungal cell wall integrity, yet the molecular basis of GPI-MT-I assembly and substrate recognition remains poorly understood. Here, we present the cryo-EM structure of

Indexed as

Candida glabratacryo-EMGPImannosyltransferase

Identifiers

PMID41295199

DOI10.3390/jof11110819

PMCPMC12653191

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.