ArticleJournal of fungi (Basel, Switzerland)2025
Diagnostic Performance of Coccidioidomycosis PCR Testing in Lung Nodules: A Retrospective Study in Central California.
Article in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Biomarkers in Invasive Pulmonary Fungal Infections: Where Do We Stand?Journal of fungi (Basel, Switzerland) · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoccidioidomycosis is an endemic fungal infection in the southwestern United States that can present as solitary lung nodules, mimicking malignancy on imaging. Molecular testing, such as PCR, offers rapid diagnosis but its performance in this clinical setting remains unclear.
methodsWe conducted a retrospective analysis of patients evaluated for lung nodules at a tertiary care community-based lung nodule clinic in Central California between 2011 and 2025.
resultsAmong 122 patients with Coccidioidomycosis, PCR demonstrated low sensitivity (range: 20-41%) but high specificity (100%) across all biopsy modalities. Histology and fungal cultures outperformed PCR, detecting additional cases missed by molecular testing. Notably, 9 PCR-negative cases were confirmed on histology, and PCR was only positive in 71.4% of culture-confirmed cases.
conclusion
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