ArticleJournal of functional biomaterials2025
Early Osseointegration in a Sheep Tibia Model: Correlating Digital Periapical Radiograph Gray-Level and RGB-Derived Metrics with Histologic Tissue Composition.
Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Influence of Reduced Cortical Bone Compression by Implant Macrogeometry on Peri-Implant Bone Healing: An In Vitro and In Vivo Experimental Study.Journal of functional biomaterials · 2026Article
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Authors and funding
10 authors.
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Abstract
objectiveThis study aimed to evaluate peri-implant tissue changes during early osseointegration using a combined approach of digital radiographic analysis, RGB pseudocolorization, and histomorphometry in a sheep tibia model. MATERIALS AND
methodsThirty titanium implants were placed in the tibiae of six adult sheep and evaluated at 14 and 28 days post-implantation. Digital periapical radiographs were acquired, grayscale values and RGB channel intensities were measured using Fiji/ImageJ, and compared with histological parameters (bone tissue, collagen, and medullary spaces) quantified from picrosirius-hematoxylin-stained sections. Manual overlay of radiographic and histological images was performed to ensure spatial correspondence of regions of interest. Statistical analyses assessed differences over time and correlations between image data and histological composition.
resultsRadiographic grayscale values and histologically measured bone and collagen increased significantly from 14 to 28 days (
conclusionsRGB pseudocolorized radiographic analysis, correlated with histological findings, offers a non-invasive and reproducible method for early detection of peri-implant tissue maturation. This feasibility correlation study provides a foundation for future investigations integrating imaging, histology, and biomechanical testing.
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