Evidence map›Paper›PMID 41295054›Full record

ArticleJournal of functional biomaterials2025

Multifunctional Peptide-Based Biohybrid for Targeted Reduction of Metastatic Breast Carcinoma-Associated Osteolysis.

Nicole Stadler, Bingjie Gao, Maria Jose Silva, Joscha Borho, Eva Haunschild, Kaloian Koynov, Melanie Haffner-Luntzer, Anita Ignatius, Gilbert Weidinger, Seah Ling Kuan and 2 more

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nicole StadlerInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081 Ulm, Germany.ORCID 0000-0001-8997-866X
Bingjie GaoMax-Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Maria Jose SilvaMax-Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Joscha BorhoInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081 Ulm, Germany.ORCID 0009-0000-6498-3649
Eva HaunschildInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Kaloian KoynovMax-Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Melanie Haffner-LuntzerInstitute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research, Ulm University Medical Center, Helmholtzstraße 14, 89081 Ulm, Germany.ORCID 0000-0002-3333-2613
Anita IgnatiusInstitute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research, Ulm University Medical Center, Helmholtzstraße 14, 89081 Ulm, Germany.ORCID 0000-0002-4782-1979
Gilbert WeidingerInstitute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.ORCID 0000-0003-3599-6760
Seah Ling KuanMax-Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.ORCID 0000-0003-3945-4491
Tanja WeilMax-Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.ORCID 0000-0002-5906-7205
Holger BarthInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

Funding

Deutsche Forschungsgemeinschaft 316249678, 251293561
6 · The paper itself

Abstract

Metastatic breast carcinoma (BC) cells are prone to spreading in the bone microenvironment, leading to a vicious cycle between local osteoclast-mediated osteolysis and tumor progression. Therefore, the targeted pharmacological down-modulation of BC cell proliferation as well as osteoclast differentiation and hyperactivity might represent a promising treatment option. We developed a multifunctional peptide nanocarrier combining bioactive EPI-X4 peptides and the Rho-inhibiting C3bot enzyme from

Indexed as

avidin/biotinC3botCXCR4EPI-X4metastatic breast cancerosteoclastosteolysisRhotargeted multifunctional nanocarrier

Identifiers

PMID41295054
PMCPMC12653180

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.