Evidence map›Paper›PMID 41294993›Full record

ArticleEntropy (Basel, Switzerland)2025

Learning in Probabilistic Boolean Networks via Structural Policy Gradients.

Pedro Juan Rivera Torres

Abstract read
In one paragraph

Article in Entropy (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Pedro Juan Rivera TorresDepartamento de Computación y Automatización, Universidad de Salamanca, CB3 0BN Salamanca, Spain.ORCID 0000-0003-3507-1821

Funding

Horizon 2020 - Marie Curie Postdoctoral Fellowships 101034371 - PROOPI445
6 · The paper itself

Abstract

We revisit Probabilistic Boolean Networks as trainable function approximators. The key obstacle, non-differentiable structural choices (which predictors to read and which Boolean operators to apply), is addressed by casting the PBN's structure as a stochastic policy whose parameters are optimized with score-function (REINFORCE) gradients. Continuous output heads (logistic/linear/softmax or policy logits) are trained with ordinary gradients. We call the resulting model a Learning PBN. We formalize the Learning Probabilistic Boolean Network, derive unbiased structural gradients with variance reduction, and prove a universal approximation property over discretized inputs. Empirically, Learning Probabilistic Boolean Networks approach ANN performance across classification (accuracy ↑), regression (RMSE ↓), representation quality via clustering (ARI ↑), and reinforcement learning (return ↑) while yielding interpretable, rule-like internal units. We analyze the effect of binning resolution, operator sets, and unit counts, and show how the learned logic stabilizes as training progresses. Our results indicate that PBNs can serve as general-purpose learners, competitive with ANNs in tabular/noisy regimes, without sacrificing interpretability.

Indexed as

Learning Probabilistic Boolean NetworksProbabilistic Boolean Networkstatistical learning

Identifiers

PMID41294993
PMCPMC12650854

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.