Evidence map›Paper›PMID 41294905›Full record

ArticleDiseases (Basel, Switzerland)2025

Residual Platelet Reactivity and Dyslipidemia in Post-CABG Patients Undergoing Repeat Revascularization: Insights from Kazakhstan.

Aisulu Mussagaliyeva, Sholpan Zhangelova, Laura Danyarova, Friba Nurmukhammad, Dina Kapsultanova, Orazbek Sakhov, Farida Rustamova, Akhmetzhan Sugraliyev, Dana Akhmentayeva

Abstract read
In one paragraph

Article in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aisulu MussagaliyevaDepartment of Postgraduate and Continuing Education, Scientific Research Institute of Cardiology and Internal Diseases, Almaty 050000, Kazakhstan.
Sholpan ZhangelovaDepartment of Postgraduate and Continuing Education, Scientific Research Institute of Cardiology and Internal Diseases, Almaty 050000, Kazakhstan.ORCID 0000-0003-3702-5642
Laura DanyarovaDepartment of Postgraduate and Continuing Education, Scientific Research Institute of Cardiology and Internal Diseases, Almaty 050000, Kazakhstan.ORCID 0000-0003-0143-3847
Friba NurmukhammadDepartment of Postgraduate and Continuing Education, Scientific Research Institute of Cardiology and Internal Diseases, Almaty 050000, Kazakhstan.ORCID 0000-0002-6312-4479
Dina KapsultanovaDepartment of Postgraduate and Continuing Education, Scientific Research Institute of Cardiology and Internal Diseases, Almaty 050000, Kazakhstan.
Orazbek SakhovFaculty of Postgraduate Education, Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.
Farida RustamovaFaculty of Postgraduate Education, Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.ORCID 0000-0002-5259-6171
Akhmetzhan SugraliyevFaculty of Postgraduate Education, Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.ORCID 0000-0002-8255-4159
Dana AkhmentayevaDepartment of Postgraduate and Continuing Education, Scientific Research Institute of Cardiology and Internal Diseases, Almaty 050000, Kazakhstan.ORCID 0000-0001-9395-8397

Funding

Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan "Improving the outcomes of surgical myocardial revascularization based on the development of comprehensive innovative management of pa-tients after interven "IRN AR19680319".
6 · The paper itself

Abstract

backgroundCoronary artery bypass grafting (CABG) remains a standard revascularization strategy for patients with advanced coronary artery disease (CAD). However, a considerable proportion of patients experience recurrent ischemia requiring repeat revascularization. Residual platelet reactivity (RPR) and dyslipidemia are recognized as key factors contributing to graft failure and disease progression.

methodsThis observational study was conducted at a tertiary cardiology center in Kazakhstan. A total of 195 post-CABG patients who underwent repeat coronary angiography between 2023 and 2024 recruitment period for recurrent ischemic symptoms within 6-36 months after surgery were included. Clinical characteristics, comorbidities, lipid profiles, and antiplatelet response were analyzed. RPR was measured using the VerifyNow P2Y12 assay when available. Dyslipidemia was defined according to the 2019 and 2021 European guidelines.

resultsElevated RPR was identified in 45% of patients (

conclusionsResidual platelet reactivity and dyslipidemia are common and clinically relevant predictors of repeat revascularization after CABG. Optimization of antiplatelet and lipid-lowering therapy should be prioritized in secondary prevention for this high-risk population. These findings are particularly important in Kazakhstan, where post-CABG management strategies warrant further improvement.

Indexed as

coronary artery bypass graftingdual antiplatelet therapydyslipidemiaKazakhstanrepeat revascularizationresidual platelet reactivity

Identifiers

PMID41294905
PMCPMC12651223

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