Evidence map›Paper›PMID 41294860›Full record

ArticleCells2025

Single-Cell Cloning and Transcriptomic Analysis Support a Myogenic Origin of Bovine Intramuscular Adipocytes.

Zhendong Tan, Binod Pokhrel, Honglin Jiang

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhendong TanSchool of Animal Sciences, Virginia Tech, Blacksburg, VA 24061, USA.
Binod PokhrelSchool of Animal Sciences, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0003-3647-0031
Honglin JiangSchool of Animal Sciences, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0001-9540-5788

Funding

USDA NIFA 2021-67015-33398
6 · The paper itself

Abstract

Intramuscular fat (IMF) refers to the adipose tissue located between muscle fibers and is a major determinant of meat quality in cattle. The cellular origin of bovine intramuscular adipocytes remains unclear. Therefore, the objective of this study was to investigate this origin. We derived single-preadipocyte clones from IMF and subcutaneous fat (SF) of cattle through single-cell cloning and subsequent validation of their potential to differentiate into adipocytes. Transcriptomic analysis of selected single-preadipocyte clones revealed that although both IMF- and SF-derived preadipocyte clones expressed classical preadipocyte markers such as

Indexed as

AdipocytesGene Expression ProfilingMuscle DevelopmentMuscle, SkeletalSingle-Cell AnalysisTranscriptomeAdipogenesisAnimalsCattleCell DifferentiationClone CellsSatellite Cells, Skeletal MuscleSubcutaneous Fatadipogenicintramuscular fatmyogenicpreadipocytessubcutaneous fat

Identifiers

PMID41294860
PMCPMC12650837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.