ReviewCells2025
NuMA and Ninein: Dynein Cargo-Adaptors Without a Classical Cargo.
Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Dynein is a minus-end-directed microtubule motor that transports a variety of cargoes. Cargo specificity is mediated by a class of adaptor proteins that bind to the interface between dynein and dynactin, along the length of the Arp1 filament of dynactin, and that co-activate the motor. NuMA, ninein, and ninein-like protein (Nlp) are cargo-adaptors that are involved in microtubule organization, rather than carrying portable cargoes. At the same time, ninein and Nlp are believed to be anchorage factors for gamma-tubulin ring complexes to the centrosome. Here, we discuss recent findings on the interaction of NuMA and ninein with the dynein/dynactin complex, and how these findings challenge earlier concepts on ninein-dependent microtubule organization via gamma-tubulin complexes. We do not intend to provide an encyclopedic review on NuMA and ninein, but rather develop a hypothesis about how conformational changes may regulate the activities and binding specificities of these two proteins.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.