Evidence map›Paper›PMID 41294823›Full record

ArticleCells2025

WHITE MATTER MATTERS: New Approach to the Brain's Hidden Half Using Circulating Oligodendrocyte-Derived Extracellular Vesicles.

Masato Mitsuhashi, Dennis Van Epps, Haiping Sun, Li Xing, Keisuke Kawata, Viviana Jimenez, Vernon B Williams, Cina Sasannejad, Michael L James, Matthew A Edwardson and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Masato MitsuhashiNanoSomiX, Inc., Irvine, CA 92618, USA.ORCID 0000-0002-3392-140X
Dennis Van EppsNanoSomiX, Inc., Irvine, CA 92618, USA.
Haiping SunIrvine Materials Research Institute, University of California-Irvine, Irvine, CA 92697, USA.ORCID 0009-0006-5328-7342
Li XingIrvine Materials Research Institute, University of California-Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-7612-602X
Keisuke KawataKinesiology, School of Public Health, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0003-4135-9311
Viviana JimenezCenter for Sports Neurology & Pain Medicine, Cedars-Sinai Kerlan-Jobe Institute, Los Angeles, CA 90045, USA.
Vernon B WilliamsCenter for Sports Neurology & Pain Medicine, Cedars-Sinai Kerlan-Jobe Institute, Los Angeles, CA 90045, USA.ORCID 0009-0003-8648-2628
Cina SasannejadDepartment of Neurology, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-6617-567X
Michael L JamesDuke Clinical Research Institute, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-8715-5210
Matthew A EdwardsonNeurology & Rehabilitation Medicine, Georgetown University, Washington, DC 20007, USA.ORCID 0000-0002-0327-5531
Takuya MurataDepartment of Obstetrics and Gynecology, Kawasaki Medical School General Medical Center, Okayama 700-8505, Japan.ORCID 0000-0001-8449-9053

Funding

Institutional Career Development CoreKL2TR001432 · NCATS · GEORGETOWN UNIVERSITY · PI UMANS, JASON G · 2015 to 2024
$7.5M
Subconcussive neurodegenerative progression in adolescent athletesR01NS113950 · NINDS · TRUSTEES OF INDIANA UNIVERSITY · PI KAWATA, KEISUKE · 2021 to 2025
$2.8M
Stroke National Capital Area Network for Research (SCANR)U10NS086513 · NINDS · MEDSTAR HEALTH RESEARCH INSTITUTE · PI DROMERICK, ALEXANDER W, HSIA, AMIE · 2013 to 2017
$1.8M
Duke university N/AKawasaki Medical School N/ANanoSomiX, Inc. N/ANational Science Foundation DMR-2011967NCATS NIH HHS KL2 TR001432NINDS NIH HHS 1R01NS113950NINDS NIH HHS 1U10NS086513NINDS NIH HHS R01 NS113950NINDS NIH HHS U10 NS086513Spinal Cord & Brain Injury Research Fund from the Indiana State Department of Health 1U10NS086513
6 · The paper itself

Abstract

White matter, comprising 60% of the human brain, is formed by axonal fibers supported by oligodendrocytes. It is essential for brain communication, yet damage can accumulate silently leading to severe neurological problems. Current diagnostics detect changes only after symptoms appear. To enable earlier detection damage, we developed a blood test monitoring changes in oligodendrocyte-derived extracellular vesicles (ODEs) released from the brain into circulation. After validating the assay, we have shown that ODE levels vary from different individuals. However, ODE levels remain stable under mild head impacts in soccer heading practice (

Indexed as

BrainExtracellular VesiclesOligodendrogliaWhite MatterAdultFemaleHumansMaleMiddle Agedblood testextracellular vesiclesoligodendrocyteswhite matter

Identifiers

PMID41294823
PMCPMC12651410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.