Evidence map›Paper›PMID 41294816›Full record

ArticleCells2025

Calmodulin D133H Disrupts Ca

Nitika Gupta, Liam F McCormick, Ella M B Richards, Kirsty Wadmore, Rachael Morris, Vanessa S Morris, Pavel Kirilenko, Ewan D Fowler, Caroline Dart, Nordine Helassa

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nitika GuptaDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZB, UK.ORCID 0000-0003-3885-2500
Liam F McCormickDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZB, UK.ORCID 0000-0001-9557-9403
Ella M B RichardsDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZB, UK.
Kirsty WadmoreDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZB, UK.
Rachael MorrisDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZB, UK.
Vanessa S MorrisDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZB, UK.
Pavel KirilenkoSchool of Biosciences, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF10 3AX, UK.
Ewan D FowlerSchool of Biosciences, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF10 3AX, UK.ORCID 0000-0001-5580-2156
Caroline DartDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZB, UK.
Nordine HelassaDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZB, UK.ORCID 0000-0003-3743-1886

Funding

Biotechnology and Biological Sciences Research Council BB/V002767/1British Heart Foundation FS/17/56/32925British Heart Foundation FS/EXT/22/35014British Heart Foundation FS-IBSRF- 21-25071British Heart Foundation FS/PhD/20/29025British Heart Foundation FS/PhD/22/29339Heart Research WalesUniversity of Liverpool ITMWellcome TrustWellcome Trust 102172/B/13/Z
6 · The paper itself

Abstract

Calmodulin (CaM) plays a central role in cardiac excitation-contraction coupling by regulating ion channels, including the L-type calcium (Ca

Indexed as

Action PotentialsCalcium Channels, L-TypeCalmodulinKCNQ1 Potassium ChannelLong QT SyndromeAnimalsCalciumHEK293 CellsHumansMutationCalciumCalcium Channels, L-TypeCalmodulinKCNQ1 Potassium Channelcalcium-dependent inactivation (CDI)calcium signallingcalmodulincardiac arrhythmiaCav1.2 (L-type calcium channel)channelopathiesD133H mutationion channel regulationKv7.1 (KCNQ1 potassium channel)long QT syndrome

Identifiers

PMID41294816
PMCPMC12651261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.