Evidence map›Paper›PMID 41294815›Full record

ReviewCells2025

Cardiac SR-Mitochondria Contacts-Impact on Cardiac Physiology and Mitochondrial Fitness.

Celia Fernandez-Sanz, Shey-Shing Sheu, Sergio De la Fuente

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Celia Fernandez-SanzCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-0809-0675
Shey-Shing SheuCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0003-3838-3601
Sergio De la FuenteCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-8021-2390

Funding

Mitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ DynamicsR01HL122124 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2014 to 2025
$4.0M
Dynamin-Related Protein Drp1 Regulates Cardiac Excitation-Contraction-Bioenergetics CouplingR01HL137266 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI SHEU, SHEY-SHING, WANG, WANG · 2018 to 2021
$2.5M
Structural-functional zoning of the mitochondrion in cardiac Ca2+, ROS, and energetics regulationR01HL142864 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2018 to 2021
$2.5M
Optimice 100-Cage IVC SystemS15OD039813 · OD · THOMAS JEFFERSON UNIVERSITY · PI LATOURETTE, PHIL · 2025 to 2025
$348k
American Heart Association 20POST35211149NHLBI NIH HHS R01 HL122124NHLBI NIH HHS R01 HL137266NHLBI NIH HHS R01 HL142864NIH HHS 1R01HL122124NIH HHS 1R01HL137266NIH HHS S15 OD039813
6 · The paper itself

Abstract

In adult cardiomyocytes, within the Mitochondrial Associated Membranes (MAMs), the sarcoplasmic reticulum (SR) and mitochondria juxtapose each other, forming a unique and highly repetitive functional structure throughout the cells. These SR-mitochondria contact sites have emerged as critical structures that regulate various physiological processes, including lipid exchange, calcium (Ca

Indexed as

Mitochondria, HeartMyocytes, CardiacSarcoplasmic ReticulumAnimalsCalciumHumansMitochondrial MembranesCalciumbioenergeticsheartMAMsmicrodomainsmitochondriaSR

Identifiers

PMID41294815
PMCPMC12651723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.