Evidence map›Paper›PMID 41294804›Full record

ArticleCells2025

Epicardial Abnormalities and Mesenchymal/Hematopoietic Cell Expansion in Plakophilin 2-Null Mouse Embryonic Hearts.

Mistura Dolapo Bolaji, Pia E Hartmann, Eva Miriam Buhl, Robin M W Colpaert, Francesca Gasparella, Leon J de Windt, Martina Calore, Rudolf E Leube, Hoda Moazzen

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mistura Dolapo BolajiInstitute of Molecular and Cellular Anatomy, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany.
Pia E HartmannSchool of Cardiovascular Disease (CARIM), Faculty of Health, Medicine & Life Sciences (FHML), Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.ORCID 0009-0001-7452-5462
Eva Miriam BuhlElectron Microscopy Facility, Institute of Pathology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany.ORCID 0000-0003-0627-9228
Robin M W ColpaertSchool of Cardiovascular Disease (CARIM), Faculty of Health, Medicine & Life Sciences (FHML), Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.ORCID 0000-0001-7689-4467
Francesca GasparellaDepartment of Biology, Padova University, via Ugo Bassi 58B, 35131 Padova, Italy.ORCID 0009-0008-8731-6273
Leon J de WindtSchool of Cardiovascular Disease (CARIM), Faculty of Health, Medicine & Life Sciences (FHML), Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.ORCID 0000-0002-7793-2856
Martina CaloreSchool of Cardiovascular Disease (CARIM), Faculty of Health, Medicine & Life Sciences (FHML), Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.ORCID 0000-0003-4751-1476
Rudolf E LeubeInstitute of Molecular and Cellular Anatomy, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany.ORCID 0000-0002-5519-7379
Hoda MoazzenInstitute of Molecular and Cellular Anatomy, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany.ORCID 0000-0002-8607-6545

Funding

Cardinnov-RECREATE of the Dutch Research Council (NWO) GA N° 101095426DELIVERANCE LSHM202313Fondazione Cariparo Starting Package C93C22008360007Horizon-EIC-2022-Pathfinder IMPACT; 101115536Telethon foundation grant GMR24T1105Topconsortia for Knowledge and Innovation Health~Holland projects CARDIOIDS LSHM21068Universitätsklinikum Aachen 81-02.04.2020.A323
6 · The paper itself

Abstract

Desmosomal junctions provide structural stability supporting concerted cardiomyocyte contractility. Previously, we demonstrated that a deficiency in the desmosomal transmembrane cadherin desmoglein 2 (Dsg2) reduces desmosome formation and disrupts cardiac morphogenesis, leading to excessive endothelial-to-hematopoietic cell transformation and embryonic lethality. It remained unclear whether this phenotype was specifically driven by Dsg2-deficiency or was a broader consequence of impaired desmosome adhesion. To address this question, we generated

Indexed as

HeartHematopoietic Stem CellsMesenchymal Stem CellsPericardiumPlakophilinsAnimalsCell ProliferationDesmoglein 2DesmosomesEmbryo, MammalianMiceMice, KnockoutMyocardiumDesmoglein 2Plakophilinsdesmosomeembryonic heartheart developmenthematopoiesishemopericardiumintercellular junctionsplakophilin 2

Identifiers

PMID41294804
PMCPMC12651295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.