ArticleBiosensors2025
Microfluidic-Integrated, Ring-Resonator-Assisted Mach-Zehnder Interferometer (μFRA-MZI) as a Label-Free Nanophotonic Sensor.
Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The ring-assisted Mach-Zehnder interferometer (RA-MZI) has high sensitivity and fast optical response time, and it has been used as a label-free nanophotonic biosensor. Most RA-MZI-based biosensors, however, require chemical modification of the ring surface to immobilize biomolecules that can interact with target molecules for sensing. Here, we report a novel microfluidic-integrated RA-MZI (μFRA-MZI) where a microfluidic channel was fabricated right above the photonic ring resonator. μFRA-MZI allows for direct sample delivery to the RA-MZI without chemical modification of the ring surface and measures shifts in the resonance wavelength induced by the presence of target molecules, enabling label-free detection. In order to optimize the sensitivity of μFRA-MZI, seven devices were fabricated with varied design parameters, including the gap distance between the ring and the bus waveguide (G
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