Evidence map›Paper›PMID 41294749›Full record

ArticleBiosensors2025

Electrochemical Tracking of Macrophage Migration Inhibitory Factor: A Leap Toward Precision Colorectal Cancer Diagnosis and Prognosis.

Eloy Povedano, Antonino-Biagio Carbonaro, Verónica Serafín, María Gamella, Alessandro Giuffrida, Ana Montero-Calle, José Manuel Pingarrón, Rodrigo Barderas, Susana Campuzano

Abstract read
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eloy PovedanoDepartment of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, 28040 Madrid, Spain.
Antonino-Biagio CarbonaroDepartment of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0003-4393-990X
Verónica SerafínDepartment of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, 28040 Madrid, Spain.
María GamellaDepartment of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, 28040 Madrid, Spain.
Alessandro GiuffridaDepartment of Chemical Sciences, University of Catania, 95100 Catania, Italy.ORCID 0000-0003-3497-2759
Ana Montero-CalleChronic Disease Programme, UFIEC, Institute of Health Carlos III, Majadahonda, 28220 Madrid, Spain.ORCID 0000-0001-5141-0454
José Manuel PingarrónDepartment of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0003-2271-1383
Rodrigo BarderasChronic Disease Programme, UFIEC, Institute of Health Carlos III, Majadahonda, 28220 Madrid, Spain.ORCID 0000-0003-3539-7469
Susana CampuzanoDepartment of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-9928-6613

Funding

AES-ISCIII PI20CIII/00019AES-ISCIII PI23CIII/00027Ministerio de Ciencia e Innovación PID2022-136351OB-I00Ministerio de Ciencia e Innovación PID2022-140307OB-I00
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a significant global health burden, mainly due to late diagnosis and chemotherapy resistance. Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine associated with tumor progression, has emerged as a promising biomarker in CRC. However, its clinical utility is limited by the lack of rapid and accessible detection methods. In this study, we report an electrochemical immunotechnology for the sensitive and selective quantification of MIF protein in CRC tissue samples. By combining magnetic microparticles (MMPs), antibody-based recognition, horseradish peroxidase (HRP) labeling, and amperometric transduction at disposable screen-printed carbon electrodes (SPCEs), the developed methodology displayed a linear dynamic range from 0.24 to 20 ng mL

Indexed as

Biosensing TechniquesColorectal NeoplasmsElectrochemical TechniquesMacrophage Migration-Inhibitory FactorsBiomarkers, TumorHumansIntramolecular OxidoreductasesPrognosisBiomarkers, TumorIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMIF protein, humancolorectal cancerdiagnosiselectrochemical biotechnologymacrophage migration inhibitory factor MIFprognosisstaging

Identifiers

PMID41294749
PMCPMC12650599

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.