Evidence map›Paper›PMID 41294631›Full record

ArticleClinics and practice2025

Advancing Toward P6 Medicine: Recommendations for Integrating Artificial Intelligence in Internal Medicine.

Ismael Said-Criado, Filomena Pietrantonio, Marco Montagna, Francesco Rosiello, Oleg Missikoff, Carlo Drago, Tiffany I Leung, Antonio Vinci, Alessandro Signorini, Ricardo Gómez-Huelgas and 1 more

Abstract read
In one paragraph

Article in Clinics and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ismael Said-CriadoPalliative Care Unit, Internal Medicine Department, Pontevedra's Hospital, Healthcare Research Institute Galicia Sur, 36001 Pontevedra, Spain.ORCID 0000-0003-4094-5343
Filomena PietrantonioInternal Medicine Unit, Medical Area Department, Castelli Hospital, ASL Roma 6, Ariccia, 00040 Rome, Italy.ORCID 0000-0003-1119-0869
Marco MontagnaDepartment of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0002-0907-7640
Francesco RosielloDepartment of Public Health and Internal Medicine, Sapienza Università di Roma, 00185 Rome, Italy.ORCID 0000-0002-6532-1185
Oleg MissikoffDepartment of European, American and Intercultural Studies, Sapienza University of Rome, 00185 Rome, Italy.
Carlo DragoDepartment of Economics, Psychology, Communication, Education and Motor Sciences, Niccolò Cusano University, 00166 Rome, Italy.ORCID 0000-0002-3920-0267
Tiffany I LeungDepartment of Internal Medicine (Adjunct), Southern Illinois University School of Medicine, Springfield, IL 62794, USA.
Antonio VinciDoctoral School in Nursing Sciences and Public Health, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-4915-7733
Alessandro SignoriniHealth Technology Assessment (HTA) Unit, Saint Camillus International University of Health Sciences, 00131 Rome, Italy.ORCID 0000-0002-9768-3252
Ricardo Gómez-HuelgasInternal Medicine Department, Hospital Regional Universitario de Málaga, University of Málaga, 29010 Malaga, Spain.ORCID 0000-0002-9909-3555
EFIM Telemedicine, Innovative Technologies and Digital Health Working Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInternists formulate diagnostic hypotheses and personalized treatment plans by integrating data from a comprehensive clinical interview, reviewing a patient's medical history, physical examination and findings from complementary tests. The patient treatment life cycle generates a significant volume of data points that can offer valuable insights to improve patient care by guiding clinical decision-making. Artificial Intelligence (AI) and, in particular, Generative AI (GAI), are promising tools in this regard, particularly after the introduction of Large Language Models. The European Federation of Internal Medicine (EFIM) recognizes the transformative impact of AI in leveraging clinical data and advancing the field of internal medicine. This position paper from the EFIM explores how AI can be applied to achieve the goals of P6 Medicine principles in internal medicine. P6 Medicine is an advanced healthcare model that extends the concept of Personalized Medicine toward a holistic, predictive, patient-centered approach that also integrates psycho-cognitive and socially responsible dimensions. An additional concept introduced is that of Digital Therapies (DTx), software applications designed to prevent and manage diseases and disorders through AI, which are used in the clinical setting if validated by rigorous research studies.

methodsThe literature examining the relationship between AI and Internal Medicine was investigated through a bibliometric analysis. The themes identified in the literature review were further examined through the Delphi method. Thirty international AI and Internal Medicine experts constituted the Delphi panel.

resultsDelphi results were summarized in a SWOT Analysis. The evidence is that through extensive data analysis, diagnostic capacity, drug development and patient tracking are increased.

conclusionsThe panel unanimously considered AI in Internal Medicine as an opportunity, achieving a complete consensus on the matter. AI-driven solutions, including clinical applications of GAI and DTx, hold the potential to strongly change internal medicine by streamlining workflows, enhancing patient care and generating valuable data.

Indexed as

artificial intelligenceDelphi methodinternal medicineP6 MedicineSWOT analysis

Identifiers

PMID41294631
PMCPMC12651712

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.