ArticleGels (Basel, Switzerland)2025
Response Surface Methodology Optimization of Electron-Beam-Irradiated Carboxymethyl Cellulose/Citric Acid-Based Hydrogels.
Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Electron beam irradiation (EBI) is an environmentally friendly cross-linking technique that can form covalent bonds between natural polymers without the use of chemical cross-linkers. In this study, carboxymethyl cellulose (CMC; 3000 cPs) and citric acid (CA) were used to prepare hydrogels under low-dose EBI conditions (7 kGy). The effects of composition variables were statistically analyzed using response surface methodology based on central composite design. The concentrations of CMC (4-14 wt%) and CA (1-4 wt%) were selected as independent variables, while the gel fraction, water absorption, and elastic modulus were employed as responses. Analysis of variance confirmed that the quadratic models were statistically significant (
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