ArticleGels (Basel, Switzerland)2025
Synthesis and Evaluation of Carbon Black-Containing Hydrogels for the Adsorption of 5-Fluorouracil.
Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The widely used anticancer drug 5-Fluorouracil (5-FU) may potentially elicit adverse side effects on the eyes. To address this problem, we aimed to synthesize hydrogels containing carbon black (CB), a porous material, for use as a 5-FU-adsorbent contact lens material. High-performance liquid chromatography revealed a direct correlation between the specific surface area of CB particles and 5-FU adsorption. CB particles with functional surface groups were characterized by superior dispersibility in monomer solutions, whereas the results of combustion ion chromatography indicated that 5-FU adsorption was higher for hydrogels with a higher water content and that the addition of CB to the hydrogel further enhanced the rate of 5-FU adsorption by 21%. In addition, 5-FU was strongly fixed within the CB-printed hydrogel matrix even after washing, with hydrophobic interactions with CB being established to be highly effective for binding 5-FU. Collectively, the findings of our study revealed that CB-printed hydrogel is a promising novel material for fabricating 5-FU-trapping contact lenses.
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