Evidence map›Paper›PMID 41294544›Full record

ReviewGels (Basel, Switzerland)2025

Silica Aerogels in Nano Drug Delivery Systems: A Comprehensive Review from Preparation to Medical Applications.

Xinran Qian, Jialu Lu, Meili Rui, Dengyun Xu, Haohan Liu, Dongxiao Han, Tianfeng Lu, Jianming Yang, Ai Du, Lili Qin

Abstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinran QianSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.ORCID 0009-0003-8889-2145
Jialu LuShanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, School of Physics Science and Engineering, Tongji University, Shanghai 200092, China.ORCID 0000-0003-2947-4755
Meili RuiSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Dengyun XuSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.ORCID 0009-0001-6049-6760
Haohan LiuSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Dongxiao HanShanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, School of Physics Science and Engineering, Tongji University, Shanghai 200092, China.
Tianfeng LuSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.ORCID 0000-0002-1886-4144
Jianming YangShanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, School of Physics Science and Engineering, Tongji University, Shanghai 200092, China.ORCID 0000-0002-3911-9266
Ai DuShanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, School of Physics Science and Engineering, Tongji University, Shanghai 200092, China.ORCID 0000-0002-6113-6185
Lili QinSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.ORCID 0000-0002-6005-6984

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silica aerogel has garnered significant attention in the biomedical field, primarily due to its unique combination of a three-dimensional structure, low density, tunable nanoscale pores, and an extensive surface area. These intrinsic properties render it as an exceptional candidate for advanced drug delivery systems (DDSs). In the realm of medical applications, silica aerogels have demonstrated remarkable potential, especially in nanoscale DDSs. Traditional drug delivery methods, such as capsules and tablets, are often plagued by several drawbacks, including poor bioavailability, lack of target specificity, and multidrug resistance. These limitations necessitate the development of more efficient and targeted drug delivery systems. Recent advancements in the synthesis and modification of silica aerogels have significantly enhanced their biocompatibility and functionalization capabilities. These improvements have further bolstered their potential for controlled release and targeted delivery of therapeutic agents. This study is based on silica aerogel-based nanocarrier systems, providing an in-depth exploration of its fundamental principles, preparation processes, and recent advancements. Based on this, we summarize the drug delivery methods, drug release characteristics, and diverse medical applications of silica aerogels. Additionally, we discuss the challenges and future prospects of applying silica aerogels in drug delivery systems, aiming to provide a comprehensive overview of this field.

Indexed as

drug delivery systemsmedical applicationsnanomedicinesilica aerogel

Identifiers

PMID41294544
PMCPMC12651986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.