Evidence map›Paper›PMID 41294543›Full record

ArticleGels (Basel, Switzerland)2025

Bioresponsive Hydrogel for On-Demand Nonhormonal Contraception.

Giovanni M Pauletti, Pankaj Dwivedi, Ping Li, Aluet Borrego-Alvarez, Hidemi S Yamamoto, Julie Lewis, Sarah Alobaidi, Amel Ibrahim, Raina N Fichorova, Celia M Santi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giovanni M PaulettiDepartment of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, University of Health Sciences and Pharmacy in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0002-0053-4964
Pankaj DwivediDepartment of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, University of Health Sciences and Pharmacy in St. Louis, St. Louis, MO 63110, USA.
Ping LiDepartment of Obstetrics & Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-6302-4470
Aluet Borrego-AlvarezDepartment of Obstetrics & Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-9493-8387
Hidemi S YamamotoDepartment of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA 02115, USA.
Julie LewisDepartment of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA 02115, USA.
Sarah AlobaidiSchool of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin, D04 V1W8 Dublin, Ireland.
Amel IbrahimSchool of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin, D04 V1W8 Dublin, Ireland.
Raina N FichorovaDepartment of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9980-5735
Celia M SantiDepartment of Obstetrics & Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-5101-1303

Funding

SMART Polymer Fibers For Tampon-Like Nonsteroidal Contraceptive DevicesR33HD099748 · NICHD · ST. LOUIS COLLEGE OF PHARMACY · PI PAULETTI, GIOVANNI M · 2021 to 2023
$2.4M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R33HD099748 and X01HD104420NICHD NIH HHS R33 HD099748
6 · The paper itself

Abstract

The utility of bioresponsive multifunctional hydrogel compositions for biomedical applications is rapidly increasing due to the diverse array of biological stimuli that can profoundly alter physicochemical gel properties that benefit therapeutic interventions. The purpose of this research is to explore a bioresponsive hydrogel as a drug-free bioengineering concept to fortify the natural physical contraceptive barriers at the cervicovaginal junction. The results of this research demonstrate that a hydrogel comprising 4% (

Indexed as

drug-freefemale-initiatedpartner-independentphysical contraceptive barrier

Identifiers

PMID41294543
PMCPMC12652176

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.