Evidence map›Paper›PMID 41294430›Full record

ReviewBiomimetics (Basel, Switzerland)2025

Hydrogel-Based Strategies for the Prevention and Treatment of Radiation-Induced Skin Injury: Progress and Mechanistic Insights.

Yinhui Wang, Huan Liu, Yushan He, Mei Li, Jie Gao, Zongtai Han, Jiayu Zhou, Jianguo Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomimetics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yinhui WangCNNC Key Laboratory on Radio-Toxicology and Radiopharmaceutical Preclinical Evaluation, CAEA Center of Excellence on Nuclear Technology Applications for Nonclinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.ORCID 0009-0007-3022-3589
Huan LiuCNNC Key Laboratory on Radio-Toxicology and Radiopharmaceutical Preclinical Evaluation, CAEA Center of Excellence on Nuclear Technology Applications for Nonclinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Yushan HeCNNC Key Laboratory on Radio-Toxicology and Radiopharmaceutical Preclinical Evaluation, CAEA Center of Excellence on Nuclear Technology Applications for Nonclinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Mei LiCNNC Key Laboratory on Radio-Toxicology and Radiopharmaceutical Preclinical Evaluation, CAEA Center of Excellence on Nuclear Technology Applications for Nonclinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Jie GaoCNNC Key Laboratory on Radio-Toxicology and Radiopharmaceutical Preclinical Evaluation, CAEA Center of Excellence on Nuclear Technology Applications for Nonclinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Zongtai HanCNNC Key Laboratory on Radio-Toxicology and Radiopharmaceutical Preclinical Evaluation, CAEA Center of Excellence on Nuclear Technology Applications for Nonclinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Jiayu ZhouCNNC Key Laboratory on Radio-Toxicology and Radiopharmaceutical Preclinical Evaluation, CAEA Center of Excellence on Nuclear Technology Applications for Nonclinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Jianguo LiCNNC Key Laboratory on Radio-Toxicology and Radiopharmaceutical Preclinical Evaluation, CAEA Center of Excellence on Nuclear Technology Applications for Nonclinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.

Funding

the Shanxi Provincial Natural Science Foundation 202303021222405
6 · The paper itself

Abstract

Radiation-induced skin injury (RISI) is one of the most common complications of radiotherapy, severely compromising patients' quality of life. However, no standardized treatment has yet been established. Owing to their high water content, three-dimensional porous structure, excellent biocompatibility, and tunable functionalization, hydrogels have emerged as promising candidates for both the prevention and treatment of RISI. This review provides a comprehensive overview of recent advances in hydrogel-based interventions for RISI, with particular focus on material classifications and underlying mechanisms. Mechanistically, hydrogels facilitate tissue repair through multiple synergistic pathways, including antioxidation, anti-inflammation, angiogenesis, and tissue remodeling. Understanding these mechanisms not only provides a theoretical basis for the rational design of next-generation wound dressings but also enhances the translational potential of hydrogels in clinical radiotherapy. With the convergence of materials science, radiation medicine, and pharmaceutical innovation, hydrogels are poised to redefine therapeutic strategies for RISI and accelerate their clinical implementation.

Indexed as

hybrid hydrogelshydrogelmechanismsnatural polymersradiation-induced skin injurysmart hydrogelssynthetic polymers

Identifiers

PMID41294430
PMCPMC12649924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.