Evidence map›Paper›PMID 41294142›Full record

ArticleJournal of the American Heart Association2026

Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment.

Ria Göttert, Majed Kikhia, Marie-Louise Herzog, Wen Pan, Alexandra Klaus-Bergmann, January Weiner, Dieter Beule, Samuel Knauss, Golo Kronenberg, Michael Potente and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Unmasking the Hidden Burden: Inflammation and Cardiovascular DiseaseJournal of the American Heart Association · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ria GöttertCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Neurologie und Abteilung für Experimentelle Neurologie Berlin Germany.ORCID 0000-0003-4756-7381
Majed KikhiaCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Neurologie und Abteilung für Experimentelle Neurologie Berlin Germany.ORCID 0000-0002-7719-9455
Marie-Louise HerzogCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Neurologie und Abteilung für Experimentelle Neurologie Berlin Germany.
Wen PanCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Neurologie und Abteilung für Experimentelle Neurologie Berlin Germany.
Alexandra Klaus-BergmannDZHK (German Centre for Cardiovascular Research), Partner Site Berlin Germany.ORCID 0000-0002-1164-3322
January WeinerCore Unit Bioinformatics, Berlin Institute of Health at Charité Berlin Germany.
Dieter BeuleCore Unit Bioinformatics, Berlin Institute of Health at Charité Berlin Germany.
Samuel KnaussCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Neurologie und Abteilung für Experimentelle Neurologie Berlin Germany.ORCID 0000-0002-3046-9075
Golo KronenbergCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Neurologie und Abteilung für Experimentelle Neurologie Berlin Germany.ORCID 0009-0006-4254-4358
Michael PotenteDZHK (German Centre for Cardiovascular Research), Partner Site Berlin Germany.ORCID 0000-0002-5689-0036
Holger GerhardtDZHK (German Centre for Cardiovascular Research), Partner Site Berlin Germany.ORCID 0000-0002-3030-0384
Matthias EndresCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Neurologie und Abteilung für Experimentelle Neurologie Berlin Germany.ORCID 0000-0001-6520-3720
Karen GertzCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Neurologie und Abteilung für Experimentelle Neurologie Berlin Germany.ORCID 0000-0002-1203-641X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIschemic stroke remains a leading cause of morbidity and mortality worldwide, with limited treatment options available. Vascular dysfunction is a key pathomechanism, and brain endothelial cells (bECs) play a critical role in determining stroke outcomes. This study investigates the specific roles of YAP (yes-associated protein 1) and TAZ (WW domain containing transcription regulator 1) in regulating bEC functions during stroke.

methodsMice underwent 30-minute middle cerebral artery occlusion (MCAo) followed by reperfusion to model ischemic stroke. TAZ reporter mice were used to track stroke-induced subcellular changes in TAZ expression. Tamoxifen-inducible endothelial-specific

resultsMiddle cerebral artery occlusion/reperfusion regulated

conclusionsOur data suggest that endothelial YAP/TAZ affects the inflammatory milieu subacutely after ischemia and thereby influences the chronic course of stroke. Modulation of YAP/TAZ activity in ECs may be a promising therapeutic target to promote neuroprotection after stroke.

Indexed as

BrainEndothelial CellsInfarction, Middle Cerebral ArteryIschemic StrokeTrans-ActivatorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsAdaptor Proteins, Signal TransducingTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsWwtr1 protein, mouseYap1 protein, mouseYAP-Signaling Proteinsendothelial cellsinflammationischemic strokeneuroprotectionYAP/TAZ

Identifiers

PMID41294142
PMCPMC13055844

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.