Evidence map›Paper›PMID 41294132›Full record

ReviewJournal of the American Heart Association2026

Relevance of Clonal Hematopoiesis in Immune Cells for Degenerative Aortic Valve Stenosis.

Silvia Mas-Peiro, Stefanie Dimmeler, Andreas M Zeiher

Abstract readReview
In one paragraph

Review in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Unmasking the Hidden Burden: Inflammation and Cardiovascular DiseaseJournal of the American Heart Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Silvia Mas-PeiroGoethe University Frankfurt Frankfurt am Main Germany.ORCID 0000-0002-3828-8180
Stefanie DimmelerGoethe University Frankfurt Frankfurt am Main Germany.ORCID 0000-0002-1045-2436
Andreas M ZeiherGoethe University Frankfurt Frankfurt am Main Germany.ORCID 0000-0003-1711-5819

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP), defined as the presence of somatic mutations in subjects without other hematologic abnormalities has been recently associated with several cardiovascular diseases. Degenerative aortic valve stenosis (AVS), a prototypical cardiovascular age-related disorder resulting from calcification and inflammation processes for which no medical treatment is currently available, has become the subject of scientific research in this field. In this review we describe the clinical relevance of CHIP in patients with AVS, as well as its effects on left ventricular dysfunction and heart failure, particularly about compensatory hypertrophy and diastolic dysfunction assessed by echocardiographic parameters. CHIP-driver mutations

Indexed as

Aortic ValveAortic Valve StenosisClonal HematopoiesisAnimalsDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AHumansMutationProto-Oncogene ProteinsDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanProto-Oncogene ProteinsTET2 protein, humanaortic valve stenosisclonal hematopoiesisinflammation

Identifiers

PMID41294132
PMCPMC13055804

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.