Evidence map›Paper›PMID 41294004›Full record

ArticleeLife2025

Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC).

Constanza Salinas-Rebolledo, Javier Blesa, Guillermo Valenzuela-Nieto, David Schwefel, Natalia López-González Del Rey, Maxs Méndez-Ruette, Janine Burkhalter, Elizabeth Carrazana, Francisca Díaz-Tejeda, Ignacio Arias Catalán and 8 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Constanza Salinas-RebolledoInstitute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile.ORCID https://orcid.org/0000-0002-6220-504X
Javier BlesaHM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain.ORCID https://orcid.org/0000-0002-4257-1325
Guillermo Valenzuela-NietoBiotechnological Exploration Laboratory, Health Care Science Faculty, Universidad San Sebastian, Valdivia, Chile.
David SchwefelTechnische Universität Berlin, Chair of Bioanalytics, Berlin, Germany.ORCID https://orcid.org/0000-0002-2945-0908
Natalia López-González Del ReyHM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain.
Maxs Méndez-RuettePrograma de Doctorado en Biomedicina, Facultad de Medicina, Universidad de los Andes, Santiago, Chile.
Janine BurkhalterInstitute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile.
Elizabeth CarrazanaNeurodegenerative Diseases Laboratory, Center for Biomedicine, Universidad Mayor, Temuco, Chile.
Francisca Díaz-TejedaInstitute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile.
Ignacio Arias CatalánImmunoepigenetics Laboratory, Institute of Biochemistry and Microbiology, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile.
Claudio Cappelli LeonImmunoepigenetics Laboratory, Institute of Biochemistry and Microbiology, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile.
Natalia SalvadoresNeurodegenerative Diseases Laboratory, Center for Biomedicine, Universidad Mayor, Temuco, Chile.
Luis Federico BátizNeuroscience Program, Centro de Investigación e Innovación Biomédica (CiiB) & School of Medicine, Facultad de Medicina, Universidad de los Andes, Santiago, Chile.
Ronald JaraInstitute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile.ORCID https://orcid.org/0009-0005-2861-3911
José A ObesoHM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain.
Pedro Chana-CuevasCETRAM & Faculty of Medical Science Universidad de Santiago de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-9946-3299
Gopal P SapkotaMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, United Kingdom.ORCID https://orcid.org/0000-0001-9931-3338
Alejandro Rojas-FernandezInstitute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile.ORCID https://orcid.org/0000-0002-6004-5425

Funding

Agencia Nacional de Investigación y Desarrollo 21170632Becas Santander Iberoamerica Investigacion 2018/2019 S2017/BMD-3700Centro Ciencia ficos y Tecnológicos de Excelencia de ANID FB210008Centro Ciencia & Vida, FB210008, Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia de ANID FB210008Fondo Nacional de Desarrollo Científico y Tecnológico 1200427Fondo Nacional de Desarrollo Científico y Tecnológico 13220075Fondo Nacional de Desarrollo Científico y Tecnológico 3220635FONIS EU-LAC T010047German Research Foundation (DFG) Emmy Noether Programme SCHW1851/1-1ISCIII Miguel Servet Program CP19/00200ISCIII Miguel Servet Program FIS PI20/00496Max Planck Society 190011
6 · The paper itself

Abstract

The p97 protein is a member of the AAA+ family of ATPases. This protein is encoded by the

Indexed as

Adenosine TriphosphatasesProteolysisValosin Containing ProteinAdaptor Proteins, Signal TransducingHumansRecombinant Fusion ProteinsSingle-Domain AntibodiesAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesRecombinant Fusion ProteinsSingle-Domain AntibodiesValosin Containing ProteinVCP protein, humanalpacacell biologyhumannanobodyP97PROTACubiquitin-freeVCP

Identifiers

PMID41294004
PMCPMC12755880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.