Evidence map›Paper›PMID 41293973›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes.

Xiao Xu, Qiqing Huang, Yang Liu, Jinzhuo Liu, Deyi Yang, Yanni Song, Xin Han

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiao XuJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Qiqing HuangJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Yang LiuDepartment of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China.
Jinzhuo LiuJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Deyi YangDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150081, China.
Yanni SongDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150081, China.
Xin HanJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.ORCID https://orcid.org/0000-0002-9620-7502

Funding

Beijing MDK Public Welfare Foundation Research Fund MDK 2022-1001Guangdong Basic and Applied Basic Research Foundation 2023A1515220051Innovation Projects of State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture NZYSKL240201Jiangsu Key Discipline Construction Fund of the 14th Five-Year PlanNational Natural Science Foundation of China 32471475National Natural Science Foundation of China 82505044Pandeng Fund of Harbin Medical University Cancer Hospital PDTS 2024A-03Postdoctoral Scientific Research Developmental Fund of Heilongjiang LBH-Q22Yangtze River Delta joint sci-tech innovation and research projects 2023CSJZN0600
6 · The paper itself

Abstract

Targeting mitochondrial disruption as a strategy for inhibiting cancer cell proliferation presents a promising therapeutic approach. However, the process of mitophagy plays a protective role in cancer cells by aiding in damage repair, regulating energy metabolism, and promoting the development of drug resistance. Therefore, designing precise therapies that selectively damage mitochondria while inhibiting mitophagy remains a challenge. This study develops a biomimetic nanoplatform (MTCA@C) with hollow MnO

Indexed as

LysosomesMitochondriaNanoparticlesNeoplasmsAnimalsBenzylisoquinolinesCell Line, TumorEnergy MetabolismHumansMiceMitophagyPhotosensitizing AgentsBenzylisoquinolinesPhotosensitizing Agentstetrandrineautophagy inhibitioncancer metabolismlysosomal disruptionmacropinocytosismethuosismitochondrial targeting

Identifiers

PMID41293973
PMCPMC12866711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.