Evidence map›Paper›PMID 41293774›Full record

ArticleERJ open research2025

How do climate conditions and urbanisation impact nontuberculous mycobacterial infections? An Italian nationwide case-control study.

Paola Faverio, Lorenzo Del Castello, Maura Spotti, Paola Rebora, Enrico Cesare Maggioni, Raffaele Salerno, Alessandro Perotto, Fabrizio Luppi, Francesco Rocco Bertuccio, Stefania Reale and 18 more

Abstract read
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Paola FaverioSC di Pneumologia, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.ORCID https://orcid.org/0000-0002-0360-1237
Lorenzo Del CastelloBicocca Bioinformatics Biostatistics and Bioimaging B4 Center, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Maura SpottiInternal Medicine Department, Respiratory Unit and Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
Paola ReboraBicocca Bioinformatics Biostatistics and Bioimaging B4 Center, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Enrico Cesare MaggioniBiostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Raffaele SalernoMeteo Expert, Cinisello Balsamo, Milan, Italy.
Alessandro PerottoBiostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Fabrizio LuppiSC di Pneumologia, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.ORCID https://orcid.org/0000-0001-5775-5947
Francesco Rocco BertuccioSC di Pneumologia, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.ORCID https://orcid.org/0009-0009-7699-6610
Stefania RealeASST degli Spedali Civili di Brescia, Università di Brescia, UOC Malattie Infettive 2, Brescia, Italy.
Valentina FornariOspedale Amedeo di Savoia, Clinica Universitaria di Malattie Infettive, Turin, Italy.
Filippo GozziPulmonology, University Hospital of Modena, Modena, Italy.
Bianca GranozziInfectious Diseases Unit, Department for Integrated Infectious Risk Management, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Federico Lorenzo DenteAzienda Ospedaliero Universitaria Pisana, Dipartimento di Fisiopatologia Respiratoria e Riabilitazione Respiratoria, Pisa, Italy.
Francesca MariottiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID https://orcid.org/0009-0009-2796-8621
Jacopo SimonettiFondazione Policlinico Universitario "Agostino Gemelli", Struttura Complessa Pneumologia, Roma, Italy.
Gina GualanoIstituto Nazionale per le Malattie Infettive "L. Spallanzani" - IRCCS, UOC Malattie Infettive dell'Apparato Respiratorio, Rome, Italy.
Niccolò RiccardiInfectious Disease Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Maurizio FerrareseRegional TB Reference Centre, Istituto Villa Marelli, Niguarda Hospital, Milan, Italy.
Luigi Ruffo CodecasaRegional TB Reference Centre, Istituto Villa Marelli, Niguarda Hospital, Milan, Italy.
Giovanni SotgiuClinical Epidemiology and Medical Statistics Unit, Dept of Medical, Surgical, Experimental Sciences, University of Sassari, Sassari, Italy.ORCID https://orcid.org/0000-0002-1600-4474
Andrea GoriInfectious Diseases Unit, ASST Fatebenefratelli - Sacco, Ospedale L. Sacco, Milan, Italy.
Andrea GramegnaInternal Medicine Department, Respiratory Unit and Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.ORCID https://orcid.org/0000-0003-2315-5737
Margherita OriInternal Medicine Department, Respiratory Unit and Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
Edoardo SimonettaIRCCS Humanitas Research Hospital, Respiratory Unit, Rozzano, Italy.
Francesco BlasiInternal Medicine Department, Respiratory Unit and Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.ORCID https://orcid.org/0000-0002-2285-9970
Stefano AlibertiIRCCS Humanitas Research Hospital, Respiratory Unit, Rozzano, Italy.ORCID https://orcid.org/0000-0002-0090-4531
METEO-NTM study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Nontuberculous mycobacteria (NTM) are opportunistic pathogens primarily found in soil and water. Previous studies have linked higher population density and tropical/subtropical climates with increased NTM pulmonary disease (NTM-PD). However, the effects of meteorological parameters and population density on NTM incidence in European countries remain unclear. This study aimed to assess whether climate conditions (temperature, humidity, wind speed, precipitation) and urbanisation influence the occurrence of NTM-PD. Methods: We conducted a case-control study evaluating meteorological conditions (in the 12 months before the first NTM isolate) and urbanisation in the municipalities of residence of 1061 adults with NTM-PD enrolled in an Italian multicentre observational study (2017-2023), compared with a random sample of 10 000 adults from the Italian population. Results: The mean age of patients was 63.1 years, and 67.2% were female. Less densely populated areas were at lower risk for NTM-PD, even after adjusting for age, sex and meteorological parameters in a multivariable mixed-effects logistic regression model (OR 0.66 (95% CI: 0.56-0.78) and 0.68 (95% CI: 0.52-0.89) for semi-urban and rural areas, respectively, Conclusions: Climate change, particularly global warming and urbanisation, may increase NTM infections in regions with Mediterranean and continental climates.

Identifiers

PMID41293774
PMCPMC12643029

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