The association of late-life depressive symptoms with brain amyloid-β deposition: the ARIC-PET study.

Sylee Kanetkar, Valerie N Morrill, Marco T Egle, Keenan A Walker, Dean F Wong, Rebecca F Gottesman

Abstract read

In one paragraph

Article in Aging brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sylee KanetkarNational Institute of Neurological Disorders and Stroke, Intramural Research Program, Building 10, #4D37, 10 Center Drive, Bethesda, MD 20814, USA.

Valerie N MorrillNational Institute of Neurological Disorders and Stroke, Intramural Research Program, Building 10, #4D37, 10 Center Drive, Bethesda, MD 20814, USA.

Marco T EgleNational Institute of Neurological Disorders and Stroke, Intramural Research Program, Building 10, #4D37, 10 Center Drive, Bethesda, MD 20814, USA.

Keenan A WalkerNational Institute of Aging, Intramural Research Program, 251 Bayview Boulevard, #04B316, Baltimore, MD 21224, USA.

Dean F WongDepartments of Radiology, Neurology, Psychiatry, and Neurosciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Boulevard Suite 7, St. Louis, MO 63110, USA.

Rebecca F GottesmanNational Institute of Neurological Disorders and Stroke, Intramural Research Program, Building 10, #4D37, 10 Center Drive, Bethesda, MD 20814, USA.

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026

$65.7M

NHLBI NIH HHS U01 HL096812

6 · The paper itself

Abstract

Late-life depression is associated with an increased risk of developing dementia related to Alzheimer's disease, yet the mechanism underlying this relationship remains poorly understood. This study investigated the association of late-life depressive symptoms (LLDS) with brain amyloid deposition by PET. 334 dementia-free individuals from the Atherosclerosis Risk in Communities Study had Florbetapir-PET scans in late-life (ages 67-89). Elevated global and regional brain amyloid deposition was defined as a Florbetapir standardized uptake value ratio (SUVR) > 1.2.

Indexed as

Alzheimer’s diseaseAmyloid-betaDementiaDepressionLate-lifeLongitudinalPET

Identifiers

PMID41293752

DOI10.1016/j.nbas.2025.100152

PMCPMC12642136

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.