Evidence map›Paper›PMID 41293718›Full record

ArticleFrontiers in medicine2025

Insights into shape of uveal melanoma: a comprehensive evaluation of clinical features, pathological features, and prognosis analysis.

Heng Lou, Han Yue, Jiang Qian, Yingwen Bi, Xintong Lin, Haifeng Chen, Binbin Xu, Ruiqi Ma, Kang Xue, Jie Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heng Lou *Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Han Yue *Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Jiang QianEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Yingwen BiDepartment of Pathology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Xintong LinEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Haifeng ChenEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Binbin XuEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Ruiqi MaEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Kang XueEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Jie GuoEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Many patients with uveal melanoma (UM) cannot receive laboratory analysis due to eye-preserving treatment, biopsy risks or costs. The study is to evaluate correlation between tumor shape and a series of metastasis risks in UM, and to assess the predictive value of tumor shape classification. Methods: Four hundred thirty-nine UM patients undergoing enucleation were included in the study. Standardized echography was utilized to document selected tumor characteristics. Tumors were categorized into five distinct shape groups: mushroom, dome, lobulated, diffuse, and irregular. Clinical data, tumor thickness, largest basal diameter (LBD), American Joint Committee on Cancer (AJCC) stage, pathological results, and survival status were collected and comparatively analyzed across the different tumor shapes. Survival analysis was carried out with both Cox hazard regression and Kaplan-Meier log rank test. Results: The 439 UM cases were classified as mushroom in 164 (37.4%), dome in 129 (29.4%), lobulated in 62 (14.1%), diffuse in 11 (2.5%) and irregular in 73 (16.6%). Significant differences were observed in tumor thickness, LBD, cell type, ciliary body involvement (CBI), extraocular extension, and AJCC stage across these shape categories. Regardless of tumor size and AJCC stage, mushroom-shaped melanoma exhibited the most favorable prognosis, irregular-shaped melanoma demonstrated the worst prognosis. Conclusion: Tumor shape could be defined noninvasively and dependably using echography. Shape classification in UM provides an independent variable to improve the clinical prognostication.

Indexed as

echographymetastasisprognosistumor shapeuveal melanoma

Identifiers

PMID41293718
PMCPMC12641273

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