Evidence map›Paper›PMID 41293711›Full record

ArticleBiomedical optics express2025

Integrated fixation and stimulus channel for adaptive optics ophthalmoscopy.

Marcel T Bernucci, Yan Liu, Qiuzhi Ji, James A Crowell, Kristen Bowles-Johnson, Matthew J Keller, Donald T Miller

Abstract read
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marcel T BernucciSchool of Optometry, Indiana University, 800 Atwater Avenue, Bloomington, IN, 47405, USA.ORCID https://orcid.org/0000-0001-5674-0778
Yan LiuSchool of Optometry, Indiana University, 800 Atwater Avenue, Bloomington, IN, 47405, USA.ORCID https://orcid.org/0000-0002-5837-4908
Qiuzhi JiSchool of Optometry, Indiana University, 800 Atwater Avenue, Bloomington, IN, 47405, USA.
James A CrowellSchool of Optometry, Indiana University, 800 Atwater Avenue, Bloomington, IN, 47405, USA.
Kristen Bowles-JohnsonSchool of Optometry, Indiana University, 800 Atwater Avenue, Bloomington, IN, 47405, USA.
Matthew J KellerSchool of Optometry, Indiana University, 800 Atwater Avenue, Bloomington, IN, 47405, USA.
Donald T MillerSchool of Optometry, Indiana University, 800 Atwater Avenue, Bloomington, IN, 47405, USA.ORCID https://orcid.org/0000-0003-4395-6216

Funding

Optical Imaging of the Photoreceptor-RPE ComplexR01EY018339 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI MILLER, DONALD T · 2007 to 2025
$7.7M
Photoreceptor Disease in Inherited Retinal DegenerationsR01EY035675 · NEI · UNIVERSITY OF PENNSYLVANIA · PI ARTUR V CIDECIYAN · 2024 to 2026
$1.7M
Imaging spatial and temporal dynamics of retinal ganglion cellsR01EY029808 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI MILLER, DONALD T · 2019 to 2022
$1.7M
NEI NIH HHS R01 EY018339NEI NIH HHS R01 EY029808NEI NIH HHS R01 EY035675
6 · The paper itself

Abstract

Adaptive optics (AO) ophthalmoscopes allow high-resolution imaging of retinal structure and function at the cellular level. Due to their high magnification and small field-of-view (FOV), these systems require precise fixation and light delivery to control the retinal region being imaged and stimulated. We present a high-efficiency fixation and stimulus channel for AO ophthalmoscopy, offering an extended working distance, wide steering range, and broad dioptric correction. For stimulation, the channel delivers intense, near-monochromatic light flashes across much of the visible spectrum. Our design uses all stock components, except for a 3D-printed conic mount and a few machined parts. We balance key system trade-offs and demonstrate design performance through several AO optical coherence tomography (AO-OCT) structural and functional imaging examples. Although originally developed for the Indiana AO-OCT system, these design principles can be readily applied to other AO ophthalmoscopic platforms.

Identifiers

PMID41293711
PMCPMC12643021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.