Evidence map›Paper›PMID 41293701›Full record

ArticleBiomedical optics express2025

Deep UV laser scanning microscopy with integrated 1050 nm spectral-domain optical coherence tomography for multi-contrast tissue imaging.

Matthew T Martell, Nathaniel J M Haven, Mohammad Hadi Masoumi, Brendyn D Cikaluk, Roger J Zemp

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matthew T MartellDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada.ORCID https://orcid.org/0000-0001-9927-894X
Nathaniel J M HavenDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada.ORCID https://orcid.org/0000-0002-1090-5503
Mohammad Hadi MasoumiDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada.
Brendyn D CikalukDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada.
Roger J ZempDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada.ORCID https://orcid.org/0000-0001-6802-5624

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Slide-free microscopy methods for histological imaging in thick, minimally processed tissue specimens are rapidly emerging for surgical margin analysis applications. Here, we report an optical imaging system that combines 266 nm excited fluorescence, 266 nm confocal reflectance, and 1050 nm spectral-domain optical coherence tomography. The deep UV confocal reflectance and DAPI stain emission contrasts provide histology-like imaging at the tissue surface, with virtual H&E staining enabled by deep learning. Cross-sectional OCT extends visualization of tissue morphology beneath the specimen surface with near-infrared depth penetration. A custom reflective objective facilitates simultaneous high resolution, aberration-free imaging of UV confocal reflectance and fluorescence emission with a 0.52 numerical aperture, while transmitting a secondary low numerical aperture OCT beam. Imaging of ex vivo specimens is demonstrated in murine kidney and liver, and human breast tissues.

Identifiers

PMID41293701
PMCPMC12642977

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.