ArticleBiomedical optics express2025
Fluorescence lifetime imaging to investigate propofol-induced metabolic alterations in MDA-MB-231 cells.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Article
- Comparative Molecular Effects of Dexmedetomidine and Propofol on Osteoblast Migration and Osteogenic Gene Expression at Pediatric-Equivalent Concentrations: An In Vitro Study.Current issues in molecular biology · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
The metabolic effects of anesthetic agents like propofol on cancer cells remain poorly understood despite the widespread use of anesthesia during cancer diagnosis and treatment. Fluorescence lifetime imaging microscopy (FLIM) was used to analyze propofol-induced metabolic changes in triple-negative breast cancer cells (MDA-MB-231) by monitoring endogenous NAD(P)H and FAD fluorescence lifetimes. FLIM of propofol-treated MDA-MB-231 cells revealed concentration-dependent shifts in metabolic states that were supported by Seahorse extracellular flux analysis. While the flux analysis provided population-averaged metabolic data, FLIM enabled high-resolution, dynamic mapping of metabolism in live cancer cells. Our study highlights FLIM as a label-free tool for investigating anesthetic-induced metabolic alterations in cells, offering insights into the potential metabolic mechanisms of propofol.
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Registered trials
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