ArticleJournal of pharmacy & bioallied sciences
Cytotoxic Potential of Major Metabolites Isolated from
Article in Journal of pharmacy & bioallied sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Objective: To isolate and identify the major metabolites from the methanolic extract of C. sinaica aerial parts and evaluate their cytotoxic activity against selected human cancer cell lines. Results: Six known compounds were isolated and identified: chlorohyssopifolin A (1), cirsiliol (2), isovitexin (3), isoorientin (4), kaempferol-3-O-glucoside (5), and rutin (6), based on physical, chemical, and spectral analyses (¹H and ¹³C NMR). Cytotoxic evaluation using the sulforhodamine B assay revealed that chlorohyssopifolin A exhibited the highest activity with IC₅₀ values of 4.8 ± 0.6 µM (SKOV-3), 6.8 ± 0.5 µM (MCF-7), and 0.6 ± 0.1 µM (PC-3). Cirsiliol showed moderate cytotoxicity against PC-3 (IC₅₀ = 18.5 ± 1.6 µM), while the remaining compounds were inactive. Conclusion: Centaurea sinaica is a promising source of bioactive metabolites. Chlorohyssopifolin A displayed potent and selective cytotoxicity, particularly against prostate cancer cells, warranting further in-vivo and mechanistic studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.