ArticleJournal of pharmacy & bioallied sciences
Integrated Experimental and Computational Discovery of Repurposed and Novel Inhibitors Targeting
Article in Journal of pharmacy & bioallied sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Bacterial biofilms are highly resistant to antibiotics, leading to chronic infections. New approaches targeting biofilm formation (antivirulence) are urgently needed. Objectives: To evaluate the antibiofilm efficacy of repurposed small-molecule drugs against Methods: Twenty-nine compounds were screened for antibacterial activity (MIC) and for biofilm inhibition using microtiter plate assays. Seven lead compounds were identified and further tested for biofilm prevention and disruption. Computational studies included molecular docking of leads to key targets (e.g. Results: The lead compounds showed potent, dose-dependent inhibition of Conclusion: Repurposed small molecules can serve as effective antibiofilm agents against
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